https://scholars.lib.ntu.edu.tw/handle/123456789/436272
Title: | Modality switching between therapy and imaging based on the excitation wavelength dependence of dual-function agents in folic acid-conjugated graphene oxides | Authors: | Jun, S.W. Kwon, J. Chun, S.K. Lee, H.A. Lee, J. Hwang, D.Y. CHEN-YUAN DONG |
Issue Date: | 2018 | Journal Volume: | 9 | Journal Issue: | 2 | Start page/Pages: | 705-717 | Source: | Biomedical Optics Express | Abstract: | Owing to its near infrared (NIR) absorption, graphene oxide (GO) is promising for both photothermal (PT) therapy and multiphoton (MP) imaging. Novel therapy/imaging modality switching is proposed here based on the selected excitation wavelength of femtosecond (FS) laser. GO-based destruction of cancer cells is demonstrated when the laser power of 800-nm-wavelength FS laser is increased above 7 mW. However, GO-based imaging is mainly monitored without damaging the sample when using 1200-nm wavelength FS laser in the same laser power range. Folic acid (FA) conjugated graphene oxide (FA-GO) was synthesized for selective cancer cell targeting. Dual-function FA-GO-based cancer cell targeting agents were experimentally optimized to enable therapy/imaging modality switching. ? 2018 Optical Society of America. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/436272 | DOI: | 10.1364/BOE.9.000705 | SDG/Keyword: | Cells; Diseases; Graphene; Infrared devices; Multiphoton processes; Organic acids; Cancer cell targeting; Cancer cells; Dual function; Excitation wavelength; Femtosecond (fs) laser; Graphene oxides; Near-infrared absorption; Photo-thermal; Laser excitation; folic acid; graphene oxide; Article; atomic force microscopy; controlled study; fluorescence imaging; human; human cell; infrared spectroscopy; multiphoton microscopy; photothermal therapy; three dimensional imaging; two-dimensional imaging; ultraviolet spectroscopy |
Appears in Collections: | 物理學系 |
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