Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1
Journal
PLoS ONE
Journal Volume
13
Journal Issue
1
Date Issued
2018
Author(s)
Abstract
Static magnetic field (SMF) has shown some possibilities for cancer therapies. In particular, the combinational effect between SMF and anti-cancer drugs has drawn scientists’ attentions in recent years. However, the underlying mechanism for the drug-specific synergistic effect is far from being understood. Besides, the drugs used are all conventional chemotherapy drugs, which may cause unpleasant side effects. In this study, our results demonstrate for the first time that SMF could enhance the anti-cancer effect of natural compound, capsaicin, on HepG2 cancer cells through the mitochondria-dependent apoptosis pathway. We found that the synergistic effect could be due to that SMF increased the binding efficiency of capsaicin for the TRPV1 channel. These findings may provide a support to develop an application of SMF for cancer therapy. The present study offers the first trial in combining SMF with natural compound on anti-cancer treatment, which provides additional insight into the interaction between SMF and anti-cancer drugs and opens the door for the development of new strategies in fighting cancer with minimum cytotoxicity and side effects. ? 2018 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
SDGs
Other Subjects
calcium; capsaicin; natural product; protein Bax; protein bcl 2; vanilloid receptor 1; antineoplastic agent; calcium; capsaicin; protein Bax; TRPV1 protein, human; vanilloid receptor; antineoplastic activity; apoptosis; Article; calcium cell level; cancer inhibition; cell proliferation; cell viability; drug receptor binding; flow cytometry; Hep-G2 cell line; human; human cell; immunofluorescence microscopy; magnetic field; mitochondrion; protein expression; static magnetic field; Western blotting; drug effects; fluorescence microscopy; Hep-G2 cell line; liver tumor; magnetism; metabolism; pathology; Antineoplastic Agents; bcl-2-Associated X Protein; Blotting, Western; Calcium; Capsaicin; Cell Proliferation; Hep G2 Cells; Humans; Liver Neoplasms; Magnetics; Microscopy, Fluorescence; TRPV Cation Channels
Type
journal article