Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Bioresources and Agriculture / 生物資源暨農學院
  3. School of Veterinary Medicine / 獸醫專業學院
  4. Veterinary Medicine / 獸醫學系
  5. Areca nut extracts enhance the development of CD11b(+) Gr-1(+) cells with the characteristics of myeloid-derived suppressor cells in antigen-stimulated mice
 
  • Details

Areca nut extracts enhance the development of CD11b(+) Gr-1(+) cells with the characteristics of myeloid-derived suppressor cells in antigen-stimulated mice

Journal
Journal of Oral Pathology & Medicine
Journal Volume
40
Journal Issue
10
Pages
769-777
Date Issued
2011
Author(s)
Wang, Chia-Chi
Lin, Hung-Li
Liang, Hong-Jen
TONG-RONG JAN  
CHIA-CHI WANG  
DOI
10.1111/j.1600-0714.2011.01043.x
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/444432
Abstract
Background: Areca quid chewing is an etiological factor contributing to the development of oral cancer and pre-cancers, whose pathophysiology has been linked to inflammation and immune deterioration. Myeloid-derived suppressor cells (MDSC) play a key role in the regulation of immunity under certain pathological conditions, such as inflammation and cancer. As areca nut extracts (ANE) have been reported to induce a proinflammatory effect in antigen-stimulated mice, we hypothesized that ANE might enhance the development of MDSC. Methods: Ovalbumin (OVA)-sensitized BALB/c mice were daily administered with ANE (5-50mg/kg), polyphenol-enriched ANE (PANE; 25mg/kg) or arecoline (5mg/kg) by intraperitoneal injection for 10 doses. The mouse footpads were then subcutaneously challenged with OVA to induce local inflammatory responses. Results: ANE and PANE treatment significantly increased the spleen index and the population of CD11b +Gr-1 + cells in the spleen and peripheral blood, whereas arecoline was inactive. In addition, ANE and PANE treatment enhanced the expression of cytokines and enzymes associated with the immunosuppressive function of MDSC, including IL-10, arginase-I and iNOS in splenic CD11b + cells. Concordantly, ANE and PANE treatment augmented the infiltration of Gr-1 +IL-10 + cells in the footpads challenged with OVA. Conclusions: Our results suggested that areca nut constituents, in particular, polyphenols enhanced the development of myeloid-derived suppressor cells in vivo, which may be a critical mechanism linking inflammation and the compromised immunity reported to be associated with the pathophysiology of areca-related oral diseases. ? 2011 John Wiley & Sons A/S.
SDGs

[SDGs]SDG3

Other Subjects
areca nut extract; arecoline; arginase 1; CD11b antigen; cytokine; enzyme; inducible nitric oxide synthase; interleukin 10; ovalbumin; plant extract; polyphenol; unclassified drug; animal experiment; article; Bagg albino mouse; betel nut; blood; bone marrow cell; cell function; cell infiltration; cell maturation; controlled study; foot pad; immunostimulation; inflammation; male; mouse; nonhuman; priority journal; protein expression; spleen; suppressor cell; Animals; Antigens, CD11b; Areca; Arecoline; Arginase; Body Weight; Cell Culture Techniques; Chemotaxis, Leukocyte; Cholinergic Agonists; Immune Tolerance; Immunization; Inflammation Mediators; Interleukin-10; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred BALB C; Monocytes; Myeloid Cells; Nitric Oxide Synthase Type II; Nuts; Organ Size; Ovalbumin; Plant Extracts; Polyphenols; Receptors, Chemokine; Spleen
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science