Small angle x-ray scattering characterization of multifunctional iron oxide-pluronic nanocarriers: Effect of temperature and drug encapsulation
Journal
Nanoscience and Nanotechnology Letters
Journal Volume
8
Journal Issue
8
Pages
667-670
Date Issued
2016
Author(s)
Abstract
Present work aimed to study encapsulation of paclitaxel (PTX) and superparamagnetic iron oxide (SION) into Pluronic F127 (PEO100-PPO65-PEO100) micelles and their effect on micellar structural properties. The nuclear magnetic resonance (NMR) measurements demonstrated that PTX interacted with PPO in the micelle core whereas SION can be found in both blocks. Small angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) results highlighted that the interaction of micelles with PTX did not change the shape of the micelles. The dimensions of core and corona varied as function of drug concentration and led to the larger core upon encapsulation of the drug. The effect of temperature on the structures of Pluronic and Pluronic-PTX were also explored using SAXS. Results showed that the temperature increment from 37 to 50 C associated with micelles agglomeration and shape transition from sphere to cylinder, which are function of hydrophobicity of the micelles.
SDGs
Type
journal article