Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
Journal
Molecules
Journal Volume
20
Journal Issue
6
Pages
10910-10927
Date Issued
2015
Author(s)
Kavala, Veerababurao
Shih, Yu-Hsuan
Wang, Yu-Hsuan
Kuo, Chun-Wei
Yang, Tang-Hao
Huang, Chia-Yu
Chiu, Hao-Hsiang
Yao, Ching-Fa
Abstract
An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.
Type
journal article