https://scholars.lib.ntu.edu.tw/handle/123456789/445875
標題: | Preparation and characterization of novel water-based biodegradable polyurethane nanoparticles encapsulating superparamagnetic iron oxide and hydrophobic drugs | 作者: | YAN-PING CHEN SHAN-HUI HSU |
公開日期: | 2014 | 卷: | 2 | 期: | 21 | 起(迄)頁: | 3391-3401 | 來源出版物: | Journal of Materials Chemistry B | 摘要: | Superparamagnetic iron oxide nanoparticles (SPIO NPs) are widely used in magnetic resonance imaging and magnetic hyperthermia. In this study, we used the self-assembly behavior of biodegradable polyurethane nanoparticles (PU NPs) in water to encapsulate SPIO NPs (SPIO-PU NPs) or hydrophobic model drugs (drug-PU NPs) by an in situ method. PU NPs and SPIO-PU NPs were characterized by dynamic light scattering, transmission electron microscopy, infrared spectroscopy, and thermogravimetric analysis. The superparamagnetic property and magnetic heating ability of SPIO-PU NPs were assessed. PU NPs had no significant cytotoxicity and could be taken up by cells. SPIO-PU NPs were highly efficient in labeling cancer cells with cellular uptake of ?16 pg iron per cell on average. Hydrophobic drugs were entrapped in PU NPs effectively and showed a sustained release profile. Upon heating, the release of drug was accelerated. This proof-of-concept study demonstrated a novel way to encapsulate SPIO and hydrophobic drugs in PU NPs with smart designs for potential applications in cancer diagnostics, hyperthermia, and chemotherapy. ? the Partner Organisations 2014. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/445875 | DOI: | 10.1039/c4tb00069b | SDG/關鍵字: | Chemotherapy; Design; Infrared spectroscopy; Magnetic resonance imaging; Nanoparticles; Polyurethanes; Superparamagnetism; Thermogravimetric analysis; Transmission electron microscopy; Biodegradable polyurethanes; Cancer diagnostics; Magnetic hyperthermia; Self-assembly behaviors; Superparamagnetic iron oxide nanoparticles; Superparamagnetic iron oxides; Superparamagnetic property; Sustained release; Hydrophobicity |
顯示於: | 化學工程學系 |
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