https://scholars.lib.ntu.edu.tw/handle/123456789/447450
標題: | Assessment of mechanical integrity for drug-eluting renal stent with micro-sized drug reservoirs | 作者: | Hsiao, H.-M. Chiu, Y.-H. HAO-MING HSIAO |
關鍵字: | depot stent; drug reservoir; drug-eluting stent; renal artery stenosis; stent fatigue life | 公開日期: | 2013 | 卷: | 16 | 期: | 12 | 起(迄)頁: | 1307-1318 | 來源出版物: | Computer Methods in Biomechanics and Biomedical Engineering | 摘要: | The drug-eluting stent (DES) has become the gold standard worldwide for the treatment of cardiovascular diseases. In recent years, an innovative variation of the DES with micro-sized drug reservoirs has been introduced. It allows programmable drug delivery with both spatial and temporal control and has several potential advantages over traditional DESs. However, creating such reservoirs on the stent struts may weaken the structure of the stent scaffolding and compromise its mechanical integrity. In this study, we propose to use this innovative stent concept in the renal indication for potential treatment of both renal artery stenosis (upstream) and its associated kidney diseases (downstream) at the same time. The effects of these micro-sized drug reservoirs on several key clinically relevant functional attributes of the drug-eluting renal stent were systematically and quantitatively investigated. Finite element models were developed to predict the mechanical integrity of a balloon-expandable stent at various stages. Results show that (1) creating drug reservoirs on a stent could impact the stent fatigue resistance to certain degrees; (2) drug reservoirs on the stent crowns lead to greater loss in all key stent attributes than reservoirs on either bar arms or connectors and (3) the proposed optimised depot stent was proven to be feasible and could triple drug capacity than the current DESs, with marginal trade-off in its key clinical attributes. These results can serve as the guidelines to help future stent designs to achieve the best combination of stent structural integrity and smart drug delivery in the future. ? 2013 Taylor & Francis. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/447450 | DOI: | 10.1080/10255842.2012.670851 | SDG/關鍵字: | Cardio-vascular disease; depot stent; Drug reservoir; Drug-eluting stents; Functional attribute; Mechanical integrity; Renal artery stenosis; Smart drug deliveries; Artificial organs; Diseases; Drug delivery; Fatigue of materials; Scaffolds; Stents; antithrombocytic agent; amplitude modulation; article; biomechanics; computer model; disease association; drug delivery system; drug eluting renal stent; drug eluting stent; fatigue; finite element analysis; hemodynamics; kidney artery stenosis; neointima; priority journal; reservoir; stent thrombosis; stress strain relationship; vascularization; Drug Delivery Systems; Drug-Eluting Stents; Humans; Renal Artery Obstruction |
顯示於: | 機械工程學系 |
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