Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Bioresources and Agriculture / 生物資源暨農學院
  3. Bioenvironmental Systems Engineering / 生物環境系統工程學系
  4. Assessing the cancer risk associated with arsenic-contaminated seafood
 
  • Details

Assessing the cancer risk associated with arsenic-contaminated seafood

Journal
Journal of Hazardous Materials
Journal Volume
181
Journal Issue
1-3
Pages
161-169
Date Issued
2010
Author(s)
Chen B.-C.
Chou W.-C.
Chen W.-Y.
CHUNG-MIN LIAO  
DOI
10.1016/j.jhazmat.2010.04.112
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/448808
URL
https://www2.scopus.com/inward/record.uri?eid=2-s2.0-77954539152&doi=10.1016%2fj.jhazmat.2010.04.112&partnerID=40&md5=c766ef75edd0ffae51ef2fd0c308e980
Abstract
Tens of millions of people worldwide ingest excessive amounts of arsenic (As) through drinking water and food. The dietary intake of seafood is the major As exposure route in humans and can cause As-related adverse health effects including cancers. The aim of this study was to quantify potential cancer risks of As exposure for children and adults through seafood consumption. By coupling the age-specific physiologically based pharmacokinetic (PBPK) model and a Weibull-based dose-response function, a more accurate estimate of urinary arsenic metabolites could be achieved to better characterize potential cancer risks. The simulation results show that the proportion of inorganic As, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) in human urine are estimated to total 6.7, 26.9, and 66.4% for children, and 6.2, 27.4, and 66.4% for adults, respectively. The estimated median cumulative cancer incidence ratios were respectively 2.67×10-6 and 3.83×10-6 for children and adults, indicating a low cancer risk for local residents exposed to As through the consumption of seafood. However, it is necessary to incorporate other exposure routes into the model to make it more realistic. The methodology proposed here can not only be applied to calculate the concentrations of As metabolites in urine, but also to provide a direct estimation of adverse health effects caused by the calculated internal concentrations. ? 2010 Elsevier B.V.
Subjects
Arsenic; Cancer risk; Physiologically based pharmacokinetic model; Seafood; Urine
SDGs

[SDGs]SDG3

Other Subjects
Adverse health effects; Cancer risk; Dietary intakes; Dimethylarsinic acids; Dose response; Drinking water; Human urine; Local residents; Monomethylarsonic acids; Physiologically based pharmacokinetic model; Physiologically based pharmacokinetic models; Seafood consumption; Simulation result; Urinary arsenic; Weibull; Arsenic; Body fluids; Health risks; Meats; Metabolism; Metabolites; Pharmacokinetics; Physiological models; Potable water; Risk perception; Weibull distribution; Chemical contamination; arsenic; cacodylic acid; methanearsonic acid; arsenic; cacodylic acid; dangerous goods; organoarsenic derivative; adult; arsenic; cancer; carboxylic acid; child health; disease incidence; dose-response relationship; food consumption; health impact; health risk; ingestion rate; metabolite; numerical model; physiological response; pollution exposure; public health; risk assessment; seafood; urine; article; cancer incidence; cancer risk; metabolite; sea food; urine level; age; chemically induced; dangerous goods; environmental exposure; food contamination; human; metabolism; Neoplasms; pharmacokinetics; risk; sea food; toxicity; urine; Age Factors; Arsenic; Arsenicals; Cacodylic Acid; Environmental Exposure; Food Contamination; Hazardous Substances; Humans; Neoplasms; Pharmacokinetics; Risk; Seafood; Age Factors; Arsenic; Arsenicals; Cacodylic Acid; Environmental Exposure; Food Contamination; Hazardous Substances; Humans; Neoplasms; Pharmacokinetics; Risk; Seafood
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science