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  1. NTU Scholars
  2. 生物資源暨農學院
  3. 生物環境系統工程學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/448889
Title: Assessing health burden risk and control effect on dengue fever infection in the southern region of Taiwan
Authors: Cheng Y.-H.
Lin Y.-J.
Chen S.-C.
You S.-H.
Chen W.-Y.
Hsieh N.-H.
Yang Y.-F.
Liao C.-M.
CHUNG-MIN LIAO 
Keywords: Control intervention; DALYs; Dengue; Infection; Modeling
Issue Date: 2018
Journal Volume: 11
Start page/Pages: 1423-1435
Source: Infection and Drug Resistance
Abstract: 
Background: The high prevalence of dengue in Taiwan and the consecutive large dengue outbreaks in the period 2014–2015 suggest that current control interventions are suboptimal. Understanding the effect of control effort is crucial to inform future control strategies. Objectives: We developed a framework to measure season-based health burden risk from 2001 to 2014. We reconstructed various intervention coverage to assess the attributable effect of dengue infection control efforts. Materials and methods: A dengue–mosquito–human transmission dynamic was used to quantify the vector–host interactions and to estimate the disease epidemics. We used disability-adjusted life years (DALYs) to assess health burden risk. A temperature-basic reproduction number (R0)–DALYs relationship was constructed to examine the potential impacts of temperature on health burden. Finally, a health burden risk model linked a control measure model to evaluate the effect of dengue control interventions. Results: We showed that R0 and DALYs peaked at 25°C with estimates of 2.37 and 1387, respectively. Results indicated that most dengue cases occurred in fall with estimated DALYs of 323 (267–379, 95% CI) at 50% risk probability. We found that repellent spray had by far the largest control effect with an effectiveness of ~71% in all seasons. Pesticide spray and container clean-up have both made important contributions to reducing prevalence/incidence. Repellent, pesticide spray, container clean-up together with Wolbachia infection suppress dengue outbreak by ~90%. Conclusion: Our presented modeling framework provides a useful tool to measure dengue health burden risk and to quantify the effect of dengue control on dengue infection prevalence and disease incidence in the southern region of Taiwan. ? 2018 Cheng et al.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/448889
ISSN: 1178-6973
DOI: 10.2147/IDR.S169820
SDG/Keyword: insect repellent; pesticide; Article; controlled study; dengue; disability-adjusted life year; disease burden; epidemic; falling; incidence; infection control; mathematical model; mosquito; pesticide spraying; prevalence; risk assessment; seasonal variation; Taiwan; temperature sensitivity; virus cell interaction; virus transmission; Wolbachia
[SDGs]SDG3
Appears in Collections:生物環境系統工程學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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