https://scholars.lib.ntu.edu.tw/handle/123456789/448988
標題: | Traffic-related air pollution increased the risk of Parkinson's disease in Taiwan: A nationwide study | 作者: | Lee, Pei-Chen Liu, Li-Ling Sun, Yu Chen, Yu-An Liu, Chih-Ching Li, Chung-Yi HWA-LUNG YU Ritz, Beate |
關鍵字: | Ambient air pollution; Parkinson's disease | 公開日期: | 2016 | 卷: | 96 | 起(迄)頁: | 75-81 | 來源出版物: | Environment International | 摘要: | Background Ambient air pollution has been associated with many health conditions, but little is known about its effects on neurodegenerative diseases, such as Parkinson's disease (PD). In this study, we investigated the influence of ambient air pollution on PD in a nationwide population-based case–control study in Taiwan. Methods We identified 11,117 incident PD patients between 2007 and 2009 from the Taiwanese National Health Insurance Research Database and selected 44,468 age- and gender-matched population controls from the longitudinal health insurance database. The average ambient pollutant exposure concentrations from 1998 through the onset of PD were estimated using quantile-based Bayesian Maximum Entropy models. Basing from logistic regression models, we estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of ambient pollutant exposures and PD risk. Results We observed positive associations between NOx, CO exposures, and PD. In multi-pollutant models, for NOx and CO above the 75th percentile exposure compared with the lowest percentile, the ORs of PD were 1.37 (95% CI?=?1.23–1.52) and 1.17 (95% CI?=?1.07–1.27), respectively. Conclusions This study suggests that ambient air pollution exposure, especially from traffic-related pollutants such as NOx and CO, increases PD risk in the Taiwanese population. ? 2016 |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/448988 | ISSN: | 0160-4120 | DOI: | 10.1016/j.envint.2016.08.017 | SDG/關鍵字: | Air pollution; Health insurance; Logistic regression; Neurodegenerative diseases; Nitrogen oxides; Risk perception; Ambient air pollution; Bayesian maximum entropies; Confidence interval; Logistic regression models; Parkinson's disease; Pollutant exposures; Traffic-related air pollution; Traffic-related pollutants; Air pollution control; carbon monoxide; nitrogen oxide; ambient air; atmospheric pollution; health risk; nervous system disorder; pollution exposure; risk assessment; traffic emission; aged; air pollutant; air pollution; ambient air; Article; controlled study; environmental exposure; female; human; major clinical study; male; Parkinson disease; population based case control study; priority journal; risk assessment; Taiwan; Taiwanese; traffic; air pollution; analysis; Bayes theorem; case control study; exhaust gas; methodology; middle aged; Parkinson disease; risk factor; toxicity; very elderly; Taiwan; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Bayes Theorem; Case-Control Studies; Environmental Exposure; Female; Humans; Male; Middle Aged; Parkinson Disease; Research Design; Risk Factors; Taiwan; Vehicle Emissions |
顯示於: | 生物環境系統工程學系 |
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