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  4. Precursor-feeding strategy on the triterpenoid production and anti-inflammatory activity of Antrodia cinnamomea
 
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Precursor-feeding strategy on the triterpenoid production and anti-inflammatory activity of Antrodia cinnamomea

Journal
Process Biochemistry
Journal Volume
51
Journal Issue
8
Pages
941-949
Date Issued
2016
Author(s)
Chen, Yun-Ting
Shen, Yuh-Chiang
MEN-CHI CHANG  
Lu, Mei-Kuang
DOI
10.1016/j.procbio.2016.05.001
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/450994
URL
https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84992312308&doi=10.1016%2fj.procbio.2016.05.001&partnerID=40&md5=268b914c4e1228e1b56c7b58bdc81f85
Abstract
Antrodia cinnamomea has commercially been used in the formulation of nutraceuticals and functional foods. A. cinnamomea was fed exogenous sterols including squalene, cholesterol, and stigmasterol to enhance its triterpenoid content. Four triterpenoids were identified in A. cinnamomea, namely dehydrosulphurenic acid (De-sul), zhankuic acid A (ZaA), 15α-acetyl-dehydrosulphurenic acid (15α) and dehydroeburicoic acid (De-eb), and one polyphenyl compound, 4,7-dimethoxy-5-methyl-1,3-benzodioxole (4,7-D). Maximum ZaA and 15α contents of 2.84 and 48.07 μg/mg dry weight, respectively were achieved by 100 μM squalene-feeding, and maximum De-sul and De-eb contents of 69.08 and 47.91 μg/mg dry weight were achieved by 10 and 100 μM stigmasterol-feeding, respectively. To study the anti-inflammatory potential of A. cinnamomea, lipopolysaccharide-induced nitric oxide (NO) production, NADPH oxidase (NOX), inducible NO synthetase (iNOS) and cyclooxygenase-2 (COX-2) expression in murine microglial cells, BV-2, were evaluated. ZaA and 50 μM squalene-feeding of A. cinnamomea inhibited LPS-induced NO, iNOS and COX-2 expression in BV-2 cells. © 2016 Elsevier Ltd
Subjects
Anti-inflammation; Antrodia cinnamomea; Precursor-feeding; Squalene; Triterpenoids
Other Subjects
Alcohols; Nitric oxide
Anti-inflammation; Antrodia cinnamomea; Precursor feeding; Squalene; Triterpenoids
Type
journal article

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