Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Biochemistry and Molecular Biology / 生物化學暨分子生物學研究所
  4. Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer
 
  • Details

Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer

Journal
American Journal of Respiratory and Critical Care Medicine
Journal Volume
190
Journal Issue
4
Pages
433-444
Date Issued
2014
Author(s)
Chen C.-C.
Chen H.-Y.
KANG-YI SU  
Hong Q.-S.
BO-SHIUN YAN  
Chen C.-H.
SZU-HUA PAN  
YIH-LEONG CHANG  
Wang C.-J.
Hung P.-F.
Yuan S.
Chang G.-C.
Chen J.J.W.
PAN-CHYR YANG  
YA-CHIEN YANG  
SUNG-LIANG YU  
DOI
10.1164/rccm.201312-2256OC
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907812127&doi=10.1164%2frccm.201312-2256OC&partnerID=40&md5=ba642417f5a83af0802acf9acf3c31e7
https://scholars.lib.ntu.edu.tw/handle/123456789/452143
Abstract
Rationale: Despite advances in treatment and prognosis of non-small cell lung cancer (NSCLC), patient outcomes are still unsatisfactory. Objectives: To reduce the morbidity and mortality of patients with NSCLC, a more comprehensive understanding of mechanisms involved in cancer progression is urgently needed. Methods: By comparison of gene expression profiles in the cell line pair with differential invasion ability, CL1-0 and CL1-5, we found that Shisa3 was highly expressed in the low invasive cells. The effect of Shisa3 on invasion, migration, proliferation, apoptosis, epithelial-mesenchymal transition, and anchorage-independent growth activities in vitro and on tumor growth and metastasis in mice models were examined. The underlying mechanism of Shisa3 was explored by microarray and pathway analysis. Finally, the correlation of Shisa3 expression and clinical outcome was also calculated. Measurements and Main Results: We identified Shisa3 as a novel tumor suppressor, which induces β-catenin degradation resulting in suppression of tumorigenesis and invasion in vitro. Shisa3 decreased the tumor growth in mice with subcutaneous implantation and reduced the number of metastatic nodules in mice with tail vein injection and orthotopic implantation. Shisa3 performs the tumor suppression activity through WNT signaling predicted by microarray analysis. Our data found that Shisa3 accelerates β-catenin degradation and was positively associated with overall survival and progression-free survival of NSCLC. Conclusions: Our results reveal that Shisa3 acts as a tumor suppressor by acceleration of β-catenin degradation and provide new insight for cancer prognosis and therapy. Copyright ? 2014 by the American Thoracic Society.
SDGs

[SDGs]SDG3

Other Subjects
beta catenin; shisa3 protein; tumor suppressor protein; unclassified drug; beta catenin; membrane protein; Shisa protein, mouse; anchorage independent growth; animal experiment; animal model; apoptosis; Article; cancer growth; cancer inhibition; cancer patient; cancer survival; cell invasion; cell migration; cell proliferation; controlled study; correlational study; epithelial mesenchymal transition; gene expression profiling; human; human cell; in vitro study; lung carcinogenesis; lung function; microarray analysis; morbidity; mortality; mouse; non small cell lung cancer; nonhuman; outcome assessment; overall survival; priority journal; progression free survival; protein degradation; tail vein; tumor growth; aged; animal; article; cell motion; cell survival; disease model; genetics; lung non small cell cancer; lung tumor; metabolism; metastasis; methodology; Non-small cell lung cancer; polymerase chain reaction; SCID mouse; signal transduction; Taiwan; tumor cell culture; tumor suppressor; Western blotting; WNT signaling; metastasis; non-small cell lung cancer; tumor suppressor; WNT signaling; Aged; Animals; Apoptosis; beta Catenin; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; Humans; Lung Neoplasms; Membrane Proteins; Mice; Mice, SCID; Microarray Analysis; Polymerase Chain Reaction; Signal Transduction; Taiwan; Tumor Cells, Cultured
Publisher
American Thoracic Society
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science