|Title:||Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles||Authors:||Chen C.-L.
|Keywords:||Cancer therapy; FePt; Laser; Nanoparticle; Photothermal therapy; Thermal lens||Issue Date:||2013||Journal Volume:||34||Journal Issue:||4||Start page/Pages:||1128-1134||Source:||Biomaterials||Abstract:||
FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy. ? 2012 Elsevier Ltd.
|ISSN:||01429612||DOI:||10.1016/j.biomaterials.2012.10.044||SDG/Keyword:||Biomedical imaging; Cancer cells; Cancer therapy; Fe-Pt nanoparticle; FePt; Gold nanorod; Magnetic hyperthermia; Multi-functional materials; Near infra red; Photo-thermal; Photothermal cancer therapy; Photothermal effects; Photothermal therapy; Picoseconds; Targeted cancer therapy; Thermal lens; Threshold lasers; Transduction efficiency; Drug delivery; Gold; Infrared devices; Magnetic properties; Medical imaging; Nanomagnetics; Nanoparticles; Nanorods; Oncology; Lasers; gold nanoparticle; iron platinum nanoparticle; metal nanoparticle; nanorod; unclassified drug; article; biocompatibility; cancer cell destruction; cell membrane; femtosecond laser; high temperature; hyperthermic therapy; in vitro study; in vivo study; near infrared spectroscopy; particle size; phototherapy; photothermal cancer therapy; priority journal; Animals; Cell Line, Tumor; Hyperthermia, Induced; Iron; Laser Therapy, Low-Level; Mammary Neoplasms, Experimental; Mice; Nanoparticles; Platinum; Radiation Dosage; Treatment Outcome
|Appears in Collections:||生物化學暨分子生物學科研究所|
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