Effects of focused ultrasound and microbubbles on the vascular permeability of nanoparticles delivered into mouse tumors
Journal
Ultrasound in Medicine and Biology
Journal Volume
36
Journal Issue
9
Pages
1460-1469
Date Issued
2010
Author(s)
Abstract
Ultrasound sonication with microbubbles (MBs) was evaluated for enhancement of the release of nanoparticles from vasculature to tumor tissues. In this study, tumor-bearing Balb/c mice were insonicated with focused ultrasound (FUS) in the tumors after the injection of MBs (SonoVue?) and then lipid-coated quantum dot (LQD) nanoparticles (130 ± 25 nm) were injected through the tail vein. We studied the effects of the injected MB dose (0-300 μL/kg), sonication duration (0-300 s) and treatment-procedure sequence on the accumulation of nanoparticles in the tumors 24 h after the treatment and the time response of the accumulation (0.5-24 h). After the treatment, the mice were sacrificed and perfused and then the tumor tissues were harvested for quantifying the amount of nanoparticles using graphite furnace atomic absorption spectrometry (GF-AAS). The results showed that pulsed-FUS sonication with MBs can effectively enhance the vascular permeability for LQD nanoparticle delivery into the sonicated tumors. It indicates that this technique is promising for a better nanodrug delivery for tumor chemotherapy. ? 2010 World Federation for Ultrasound in Medicine & Biology.
SDGs
Other Subjects
BALB/c mice; Delivery enhancement; Focused ultrasound; Graphite furnace atomic absorption spectrometry; Microbubbles; Mouse tumors; Quantum Dot; Tail veins; Time response; Tumor tissues; Ultrasound sonications; Vascular permeability; Vasculature; Absorption spectroscopy; Atomic absorption spectrometry; Chemotherapy; Histology; Nanoparticles; Sonication; Ultrasonic applications; Ultrasonics; Tumors; lipid; nanoparticle; quantum dot; sonovue; animal cell; animal experiment; animal model; animal tissue; article; atomic absorption spectrometry; Bagg albino mouse; blood vessel permeability; cancer chemotherapy; cancer tissue; controlled study; dose time effect relation; drug accumulation; drug delivery system; focused ultrasound; male; microbubble; mouse; nonhuman; priority journal; ultrasound; Adenocarcinoma; Animals; Cadmium Compounds; Capillary Permeability; Colorectal Neoplasms; Male; Mice; Mice, Inbred BALB C; Microbubbles; Quantum Dots; Selenium Compounds; Spectrophotometry, Atomic; Time Factors; Tumor Cells, Cultured
Type
journal article