Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Biochemistry and Molecular Biology / 生物化學暨分子生物學研究所
  4. Effects of focused ultrasound and microbubbles on the vascular permeability of nanoparticles delivered into mouse tumors
 
  • Details

Effects of focused ultrasound and microbubbles on the vascular permeability of nanoparticles delivered into mouse tumors

Journal
Ultrasound in Medicine and Biology
Journal Volume
36
Journal Issue
9
Pages
1460-1469
Date Issued
2010
Author(s)
Lin C.-Y.
Huang Y.-L.
Li J.-R.
FU-HSIUNG CHANG  
Win-Li Lin  
DOI
10.1016/j.ultrasmedbio.2010.06.003
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956053538&doi=10.1016%2fj.ultrasmedbio.2010.06.003&partnerID=40&md5=10c74dea8c620e7c588cf433b502f3cb
https://scholars.lib.ntu.edu.tw/handle/123456789/452187
Abstract
Ultrasound sonication with microbubbles (MBs) was evaluated for enhancement of the release of nanoparticles from vasculature to tumor tissues. In this study, tumor-bearing Balb/c mice were insonicated with focused ultrasound (FUS) in the tumors after the injection of MBs (SonoVue?) and then lipid-coated quantum dot (LQD) nanoparticles (130 ± 25 nm) were injected through the tail vein. We studied the effects of the injected MB dose (0-300 μL/kg), sonication duration (0-300 s) and treatment-procedure sequence on the accumulation of nanoparticles in the tumors 24 h after the treatment and the time response of the accumulation (0.5-24 h). After the treatment, the mice were sacrificed and perfused and then the tumor tissues were harvested for quantifying the amount of nanoparticles using graphite furnace atomic absorption spectrometry (GF-AAS). The results showed that pulsed-FUS sonication with MBs can effectively enhance the vascular permeability for LQD nanoparticle delivery into the sonicated tumors. It indicates that this technique is promising for a better nanodrug delivery for tumor chemotherapy. ? 2010 World Federation for Ultrasound in Medicine & Biology.
SDGs

[SDGs]SDG3

Other Subjects
BALB/c mice; Delivery enhancement; Focused ultrasound; Graphite furnace atomic absorption spectrometry; Microbubbles; Mouse tumors; Quantum Dot; Tail veins; Time response; Tumor tissues; Ultrasound sonications; Vascular permeability; Vasculature; Absorption spectroscopy; Atomic absorption spectrometry; Chemotherapy; Histology; Nanoparticles; Sonication; Ultrasonic applications; Ultrasonics; Tumors; lipid; nanoparticle; quantum dot; sonovue; animal cell; animal experiment; animal model; animal tissue; article; atomic absorption spectrometry; Bagg albino mouse; blood vessel permeability; cancer chemotherapy; cancer tissue; controlled study; dose time effect relation; drug accumulation; drug delivery system; focused ultrasound; male; microbubble; mouse; nonhuman; priority journal; ultrasound; Adenocarcinoma; Animals; Cadmium Compounds; Capillary Permeability; Colorectal Neoplasms; Male; Mice; Mice, Inbred BALB C; Microbubbles; Quantum Dots; Selenium Compounds; Spectrophotometry, Atomic; Time Factors; Tumor Cells, Cultured
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science