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  4. Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells
 
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Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells

Journal
Journal of Materials Chemistry
Journal Volume
19
Journal Issue
32
Pages
5737-5743
Date Issued
2009
Author(s)
Tsai C.-P.
Chen C.-Y.
Hung Y.
FU-HSIUNG CHANG  
Mou C.-Y.
DOI
10.1039/b905158a
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-68349141561&doi=10.1039%2fb905158a&partnerID=40&md5=a829bd2156a46aadfcd8f5a00a45010d
https://scholars.lib.ntu.edu.tw/handle/123456789/452193
Abstract
In this work, we conjugate anti-HER2/neu mAb (monoclonal antibody) to green fluorescent dye loaded mesoporous silica nanoparticles (Her-Dye@MSN) through a polyethylene glycol (MW = 5000) spacer. We examine their targeting properties toward HER2/neu over-expressing breast cancer cells and their internalization into the cells. Her-Dye@MSN nanoparticles exhibit a high targeting efficiency and the specific targeting capability is strongly affected by the mAb density on the Her-Dye@MSN. The time-course of competitive experiments with free antibody indicates that Her-Dye@MSN serves as a multivalent ligand. Moreover, Her-Dye@MSNs are internalized into cells through a receptor-mediated endocytosis and may escape from endosome to cytosol. The results reported here further support the potential of MSNs as a multifunctional smart nanocarriers for cell imaging and drug delivery. ? 2009 The Royal Society of Chemistry.
SDGs

[SDGs]SDG3

Other Subjects
Breast cancer cells; Cell imaging; Competitive experiments; Cytosols; Endosomes; Fluorescent dyes; Functionalized; Mesoporous silica nanoparticles; Multivalent ligands; Nanocarriers; Receptor-mediated endocytosis; Targeting capability; Drug delivery; Mesoporous materials; Monoclonal antibodies; Nanoparticles; Polyethylene glycols; Polyethylene oxides; Silica; Surface plasmon resonance; Cell membranes
Type
journal article

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