https://scholars.lib.ntu.edu.tw/handle/123456789/452332
標題: | The evolution of spindles and their mechanical implications for cancer metastasis | 作者: | Chen, Yun Nam, Sungmin Chaudhuri, Ovijit HSIAO-CHUN HUANG |
關鍵字: | force generation; microtubule motors; natural and cancer evolution; Spindles | 公開日期: | 2019 | 卷: | 18 | 期: | 15 | 起(迄)頁: | 1671 - 1675 | 來源出版物: | Cell Cycle | 摘要: | The mitotic spindle has long been known to play a crucial role in mitosis, orchestrating the segregation of chromosomes into two daughter cells during mitosis with high fidelity. Intracellular forces generated by the mitotic spindle are increasingly well understood, and recent work has revealed that the efficiency and the accuracy of mitosis is ensured by the scaling of mitotic spindle size with cell size. However, the role of the spindle in cancer progression has largely been ignored. Two recent studies point toward the role of mitotic spindle evolution in cancer progression through extracellular force generation. Cancer cells with lengthened spindles exhibit highly increased metastatic potential. Further, interpolar spindle elongation drives protrusive extracellular force generation along the mitotic axis to allow mitotic elongation, a morphological change that is required for cell division. Together, these findings open a new research area studying the role of the mitotic spindle evolution in cancer metastasis. ? 2019, ? 2019 Informa UK Limited, trading as Taylor & Francis Group. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/452332 https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85068136166&doi=10.1080%2f15384101.2019.1632137&partnerID=40&md5=21bc771690e66c3fa393c33ccf3b3c35 |
ISSN: | 15384101 | DOI: | 10.1080/15384101.2019.1632137 | SDG/關鍵字: | kinesin 5; anaphase; Article; astral microtubule; cancer growth; cell size; cytokinesis; extracellular matrix; extracellular space; genetic variability; human; in vitro selection; M phase cell cycle checkpoint; metaphase; metastasis; metastasis potential; microtubule; mitosis; mitosis spindle; molecular evolution; nonhuman; telophase; tumor microenvironment; upregulation; chromosome; chromosome segregation; mitosis; spindle apparatus; Cell Size; Chromosome Segregation; Chromosomes; Mitosis; Spindle Apparatus |
顯示於: | 分子與細胞生物學研究所 |
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