https://scholars.lib.ntu.edu.tw/handle/123456789/452352
標題: | Dynamics of alternative polyadenylation in human preimplantation embryos | 作者: | Chang J.-Y. Yu W.-H. Juan H.-F. Huang H.-C. |
公開日期: | 2018 | 出版社: | Elsevier Inc. | 卷: | 504 | 期: | 4 | 起(迄)頁: | 727-733 | 來源出版物: | Biochemical and Biophysical Research Communications | 摘要: | Alternative polyadenylation (APA) affects the length of the 3′ untranslated region (3′-UTR) and the regulation of microRNAs. Previous studies have shown that cancer cells tend to have shorter 3′-UTRs than normal cells. A plausible explanation for this is that it enables cancer cells to escape the regulation of microRNAs. Here, we extend this concept to an opposing context: changes in 3′-UTR length in the development of the human preimplantation embryo. Unlike cancer cells, during early development 3′-UTRs tended to become longer, and gene expression was negatively correlated with 3′-UTR length. Moreover, our functional enrichment results showed that length changes are part of the development mechanism. We also investigated the analogy of 3′-UTR length variation with respect to lncRNAs and found that, similarly, lncRNA length tended to increase during embryo development. ? 2018 Elsevier Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/452352 | ISSN: | 0006291X | DOI: | 10.1016/j.bbrc.2018.09.027 | SDG/關鍵字: | long untranslated RNA; long untranslated RNA; RNA isoform; 3' untranslated region; Article; cancer cell; correlational study; developmental stage; embryo; embryo development; gene expression; genetic variation; genome imprinting; human; polyadenylation; preimplantation embryo; priority journal; trend study; blastocyst; gene expression regulation; gene regulatory network; genetic database; genetics; metabolism; nucleotide sequence; 3' Untranslated Regions; Base Sequence; Blastocyst; Databases, Genetic; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Polyadenylation; RNA Isoforms; RNA, Long Noncoding |
顯示於: | 分子與細胞生物學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。