|Title:||Chemical proteomics identifies heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as the molecular target of quercetin in its anti-cancer effects in PC-3 cells||Authors:||Ko C.-C.
|Issue Date:||2014||Publisher:||American Society for Biochemistry and Molecular Biology Inc.||Journal Volume:||289||Journal Issue:||32||Start page/Pages:||22078-22089||Source:||Journal of Biological Chemistry||Abstract:||
Background: Quercetin inhibits prostate cancer growth, but its mechanisms are not fully elucidated. Results: Quercetin binds to hnRNPA1 and hampers its return to the nucleus, causing accumulation of hnRNPA1 in the cytoplasm. Conclusion: hnRNPA1 is a target of quercetin, driving cells toward apoptosis through expression regulation of cIAP1. Significance: Understanding of the novel mechanism of actions on quercetin is crucial for cancer prevention and treatment in prostate cancer. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
|ISSN:||00219258||DOI:||10.1074/jbc.M114.553248||SDG/Keyword:||Cell death; Diseases; Flavonoids; Cancer prevention; Expression regulation; Heterogeneous nuclear ribonucleoprotein (hnRNP); Mechanism of action; Molecular targets; Prostate cancers; Proteomics; Phenols; antineoplastic agent; heterogeneous nuclear ribonucleoprotein; hnRNP A1; inhibitor of apoptosis protein; karyopherin beta; mutant protein; protein binding; quercetin; recombinant protein; TNPO1 protein, human; active transport; amino acid sequence; antagonists and inhibitors; apoptosis; binding site; biological model; cell survival; drug effects; genetics; human; male; metabolism; molecular genetics; phytotherapy; Prostatic Neoplasms; proteomics; tumor cell line; Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Apoptosis; beta Karyopherins; Binding Sites; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Inhibitor of Apoptosis Proteins; Male; Models, Biological; Molecular Sequence Data; Mutant Proteins; Phytotherapy; Prostatic Neoplasms; Protein Binding; Proteomics; Quercetin; Recombinant Proteins
|Appears in Collections:||生物化學暨分子生物學科研究所|
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