https://scholars.lib.ntu.edu.tw/handle/123456789/452407| Title: | Chemical proteomics identifies heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as the molecular target of quercetin in its anti-cancer effects in PC-3 cells | Authors: | Ko C.-C. Chen Y.-J. Chen C.-T. Liu Y.-C. Cheng F.-C. Hsu K.-C. LU-PING CHOW |
Issue Date: | 2014 | Publisher: | American Society for Biochemistry and Molecular Biology Inc. | Journal Volume: | 289 | Journal Issue: | 32 | Start page/Pages: | 22078-22089 | Source: | Journal of Biological Chemistry | Abstract: | Background: Quercetin inhibits prostate cancer growth, but its mechanisms are not fully elucidated. Results: Quercetin binds to hnRNPA1 and hampers its return to the nucleus, causing accumulation of hnRNPA1 in the cytoplasm. Conclusion: hnRNPA1 is a target of quercetin, driving cells toward apoptosis through expression regulation of cIAP1. Significance: Understanding of the novel mechanism of actions on quercetin is crucial for cancer prevention and treatment in prostate cancer. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905851435&doi=10.1074%2fjbc.M114.553248&partnerID=40&md5=21f9765dc650523fc89d2173e25efc73 https://scholars.lib.ntu.edu.tw/handle/123456789/452407 |
ISSN: | 00219258 | DOI: | 10.1074/jbc.M114.553248 | SDG/Keyword: | Cell death; Diseases; Flavonoids; Cancer prevention; Expression regulation; Heterogeneous nuclear ribonucleoprotein (hnRNP); Mechanism of action; Molecular targets; Prostate cancers; Proteomics; Phenols; antineoplastic agent; heterogeneous nuclear ribonucleoprotein; hnRNP A1; inhibitor of apoptosis protein; karyopherin beta; mutant protein; protein binding; quercetin; recombinant protein; TNPO1 protein, human; active transport; amino acid sequence; antagonists and inhibitors; apoptosis; binding site; biological model; cell survival; drug effects; genetics; human; male; metabolism; molecular genetics; phytotherapy; Prostatic Neoplasms; proteomics; tumor cell line; Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Apoptosis; beta Karyopherins; Binding Sites; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Inhibitor of Apoptosis Proteins; Male; Models, Biological; Molecular Sequence Data; Mutant Proteins; Phytotherapy; Prostatic Neoplasms; Protein Binding; Proteomics; Quercetin; Recombinant Proteins [SDGs]SDG3 |
| Appears in Collections: | 生物化學暨分子生物學科研究所 |
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