Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Down-regulation of CD25 expression on the surface of activated tumor- infiltrating lymphocytes in human cervical carcinoma
 
  • Details

Down-regulation of CD25 expression on the surface of activated tumor- infiltrating lymphocytes in human cervical carcinoma

Journal
Human Immunology
Journal Volume
56
Journal Issue
1-2
Pages
39-48
Date Issued
1997
Author(s)
BOR-CHING SHEU  
Lin R.-H.
HONG-NERNG HO  
Huang S.-C.
DOI
10.1016/S0198-8859(97)00111-0
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031473582&doi=10.1016%2fS0198-8859%2897%2900111-0&partnerID=40&md5=43a9d487e2999a23e2cfefa3119bbbaa
https://scholars.lib.ntu.edu.tw/handle/123456789/452571
Abstract
To investigate the activation status of tumor-infiltrating lymphocytes (TILs) within the tumor milieu of human cervical carcinoma, we quantitatively measured and compared the activation markers on lymphocyte subpopulations which infiltrating normal and neoplastic cervix. A total of 20 patients with stage IA to IIA cervical cancer (cancer group) and 10 women with normal cervix (control group) were enrolled in this study. Mononuclear cells were isolated from tissue specimens by mechanical dispersal technique and three- color flow cytometry was utilized for the quantification of activation markers on lymphocyte subsets. Compared with control group, lymphocytes isolated from cancer tissue consisted of higher proportions of B cells (7.23% ± 4.49% vs. 3.67% ± 3.19%, P = 0.016) and T cells (72.33% ± 8.70% vs. 53.15% ± 17.36%, P = 0.004), but an inverted CD4:CD8 ratio (0.74 ± 0.27 vs, 1.14 ± 0.28, P = 0.002) and decreased NK cells (7.53% ± 4.33% vs. 16.00% ± 11.82%, P = 0.035). Low expression of CD25, but not CD69 and HLA-DR was observed on both CD4+CD3+ and CD8+CD3+ T cells derived from cervical cancer (P < 0.0001). Further dual activation marker analysis demonstrated that the expression of CD25 was dissociated from CD69 and HLA-DR on the same TILs in cancer tissue (P < 0.001). TILs in the tumor microenvironment can be functionally inhibited and lose the ability of clonal proliferation due to depressed expression of CD25.
SDGs

[SDGs]SDG3

Other Subjects
cd3 antigen; cd4 antigen; cd69 antigen; cd8 antigen; HLA DR antigen; interleukin 2 receptor; phytohemagglutinin; article; b lymphocyte; clinical article; controlled study; female; flow cytometry; human; human cell; human tissue; immunophenotyping; leukocyte count; mononuclear cell; natural killer cell; priority journal; t lymphocyte; tumor associated leukocyte; uterine cervix carcinoma; Antigens, CD3; Antigens, Differentiation, T-Lymphocyte; Biological Markers; Down-Regulation; Female; HLA-DR Antigens; Humans; Immunologic Surveillance; Immunophenotyping; Lymphocyte Activation; Lymphocyte Subsets; Lymphocytes, Tumor-Infiltrating; Phytohemagglutinins; Receptors, Interleukin-2; T-Lymphocytes; Uterine Cervical Neoplasms
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science