Efficient synthesis of 'redox-switched' naphthoquinone thiol-crown ethers and their biological activity evaluation
Journal
Bioorganic and Medicinal Chemistry
Journal Volume
10
Journal Issue
6
Pages
1947 - 1952
Date Issued
2002
Author(s)
Abstract
Series of naphthoquinone thiol-crown ethers had been prepared. The antibacterial, antifungal, and cytotoxic activities of these synthetic naphthoquinone thiol-crown ethers were investigated. All of the compounds tested displayed antibacterial, cytotoxic and antifungal activities. The bis-naphthoquinone thiol-crown ether 7a was the most potent inhibitor among tested analogues against Staphylococcus aureus methicillin resistance with MIC value of 2.68 microM.
Type
journal article