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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/452710
Title: Anti-CD40 antibody and toll-like receptor 3 ligand restore dendritic cell-mediated anti-tumor immunity suppressed by morphine
Authors: Chang M.-C.
YU-LI CHEN 
YING-CHENG CHIANG 
Cheng Y.-J.
Jen Y.-W.
CHI-AN CHEN 
WEN-FANG CHENG 
Sun W.-Z.
Issue Date: 2016
Journal Volume: 157
Journal Issue: 172
Start page/Pages: 157-172
Source: American Journal of Cancer Research
Abstract: 
The influence of morphine on host immunity and the underlying mechanism are still unclear. In the current study, we investigated the influence of morphine on dendritic cells (DCs), its possible mechanism of action, and the molecules that could reverse these effects. Morphine suppressed DC maturation, antigen presenting abilities, and the ability to activate antigen-specific CD8+ T cells. Morphine-treated DCs also secreted higher concentrations of IL-10, but lower IL-6 and TNF-a. Morphine-treated DCs showed decreased ERK1/2 phosphorylation and reduced p38 dephosphorylation. The in vivo administration of immuno-modulators, anti-CD40 Ab and TLR3 ligand-poly(I:C), enhanced antigen-specific immunity, promoted the anti-tumor effects, and prolonged the survival of morphine-treated, tumor-bearing mice by promoting the maturation and function of BMM-derived DCs by enhancing ERK1/2 phosphorylation and p38 dephosphorylation. We concluded that morphine can inhibit DC-mediated anti-tumor immunity by suppressing DC maturation and function. Immuno-modulators, such as anti-CD40 Abs and TLR agonists, can restore the DC-mediated anti-tumor immunity. Use of immuno-modulators could serve as a useful approach to overcome the immunocompromised state generated by morphine.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/452710
SDG/Keyword: antibody; CD40 antibody; immunomodulating agent; interleukin 10; interleukin 6; lipopolysaccharide; mitogen activated protein kinase 1; mitogen activated protein kinase 3; morphine; polyinosinic polycytidylic acid; synaptophysin; toll like receptor 3; tumor necrosis factor alpha; unclassified drug; animal cell; animal experiment; animal model; animal tissue; antigen presentation; antineoplastic activity; Article; cancer survival; CD8+ T lymphocyte; cellular immunity; controlled study; dendritic cell; drug effect; enzyme linked immunosorbent assay; enzyme linked immunospot assay; enzyme phosphorylation; female; flow cytometry; in vitro study; in vivo study; monocyte; mouse; nonhuman; ovary cancer; protein dephosphorylation; tumor immunity; Western blotting
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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