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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/452728
Title: Screening frequency and atypical cells and the prediction of cervical cancer risk
Authors: Chen Y.-Y.
You S.-L.
Koong S.-L.
Liu J.
CHI-AN CHEN 
Chen C.-J.
Issue Date: 2014
Journal Volume: 1003
Journal Issue: 1011
Start page/Pages: 1003-1011
Source: Obstetrics and Gynecology
Abstract: 
OBJECTIVE: To evaluate the screening efficacy and importance of atypical squamous cells and atypical glandular cells in predicting subsequent cervical cancer risk. METHODS: This national cohort study in Taiwan analyzed associations between Pap test screening frequency and findings in 1995-2000 and subsequent risk of squamous cell carcinoma and adenocarcinoma after 2002. Women aged 30 years or older in 1995 without a cervical cancer history were included. Multivariate-adjusted hazard ratios and their 95% confidence intervals (CIs) were assessed using Cox regression analysis. RESULTS: During a total follow-up of 31,693,980 personyears in 2002-2008, 9,471 squamous cell carcinoma and 1,455 adenocarcinoma cases were newly diagnosed, resulting in 2,067 deaths. The risk of developing and dying from squamous cell carcinoma decreased significantly with increasing attendance frequency between 1995 and 2000 (all P values for trend <.001). Women who attended more than three screenings in 1995-2000 had 0.69-fold and 0.35-fold decrease in incidence and mortality of adenocarcinoma, respectively, compared with women who never attended any screenings. Abnormal cytologic findings were significant predictors of the incidence and mortality of cervical cancers. The adjusted hazard ratio (95% CI) of developing squamous cell carcinoma was 29.94 (22.83-39.25) for atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions, and the adjusted hazard ratio (95% CI) of developing adenocarcinoma was 49.43 (36.49-66.97) for atypical glandular cells. CONCLUSION: Significant reductions in cervical adenocarcinoma occurred in women who attend three or more annual screenings in 6 years. High-grade atypical squamous cells and atypical glandular cells are important predictors of subsequent adenocarcinoma and squamous cell carcinoma. ? 2014 by The American College of Obstetricians and Gynecologists. Published by Lippincott Williams & Wilkins.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/452728
DOI: 10.1097/AOG.0000000000000206
SDG/Keyword: adenocarcinoma; adult; aged; article; atypical glandular cell; atypical squamous cell; cancer incidence; cancer mortality; cancer risk; cancer screening; cell type; cohort analysis; female; follow up; human; human cell; human tissue; major clinical study; Papanicolaou test; priority journal; squamous cell; Taiwan; uterine cervix adenocarcinoma; uterine cervix cancer; uterine cervix carcinoma; uterine cervix carcinoma in situ; adenocarcinoma; age; Carcinoma, Squamous Cell; early diagnosis; incidence; middle aged; mortality; pathology; register; risk factor; time; Uterine Cervical Neoplasms; vagina smear; Adenocarcinoma; Adult; Age Factors; Aged; Carcinoma, Squamous Cell; Early Detection of Cancer; Female; Humans; Incidence; Middle Aged; Papanicolaou Test; Registries; Risk Factors; Taiwan; Time Factors; Uterine Cervical Neoplasms; Vaginal Smears
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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