https://scholars.lib.ntu.edu.tw/handle/123456789/452754
標題: | Risk of gynaecological malignancies in cytologically atypical glandular cells: Follow-up study of a nationwide screening population | 作者: | WEN-FANG CHENG Chen Y.-L. You S.-L. Chen C.-J. YEN-CHING CHEN CHANG-YAO HSIEH CHI-AN CHEN |
公開日期: | 2011 | 卷: | 34 | 期: | 41 | 起(迄)頁: | 34-41 | 來源出版物: | BJOG: An International Journal of Obstetrics and Gynaecology | 摘要: | Objective: To investigate the relationship between screening status, clinical characteristics and risk of gynaecological malignancies in women with a cytological diagnosis of atypical glandular cells (AGC). Design: Prospective study of a screened population. Population: Case series from nationwide screening population. Methods: The 8281 women who were diagnosed with cytological AGC for the first time were divided into screened (5386 women) and unscreened (2895 cases) groups according to their screening status. Follow-up histological reports were analysed. Main outcome measures: Diagnosis of cervical, uterine, or ovarian cancers. Results: Of the 323 women who developed gynaecological malignancies, 271 had invasive cervical cancers, 40 had uterine cancers and 12 had ovarian cancers, with a mean follow up of 1.9 years and 50 740 person-years. Previous screening status was a strong risk predictor of gynaecological malignancies (hazard ratio 1.69, P = 0.0027). Compared with the general screening population, women with a first diagnosis of cytological AGC had significantly increased ratios of developing gynaecological malignancies (17.85-fold for cervical cancer, 5.68-fold for uterine cancer, and 2.04-fold for ovarian cancer, P < 0.05). When compared with women aged <35 years, those in other age groups had a significantly higher risk of developing gynaecological cancers (age ?60 years, hazard ratio 1.99, 95% CI 1.20-2.37, P = 0.016). Conclusions: Comprehensive evaluation for women with cytological AGC, including pelvic examination, ultrasonography, colposcopy, endocervical curettage, cervical biopsy and endometrial biopsy needs to be considered, especially for those with risk factors (i.e. >60 years old, lower educational status, previous Papanicolaou smear interval longer than 2 years, or no previous Papanicolaou smear). ? RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/452754 | DOI: | 10.1111/j.1471-0528.2010.02769.x | SDG/關鍵字: | adult; article; atypical glandular cell; cancer cell; cancer risk; cancer screening; controlled study; cytology; female; follow up; gynecologic cancer; hazard ratio; high risk population; human; major clinical study; mass screening; ovary cancer; priority journal; uterine cervix cancer; Adult; Case-Control Studies; Female; Genital Neoplasms, Female; Humans; Incidence; Mass Screening; Middle Aged; Prospective Studies; Risk Factors; Taiwan; Vaginal Smears |
顯示於: | 醫學系 |
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