|Title:||Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman||Authors:||CHIN-JUI WU
|Issue Date:||2018||Journal Volume:||97||Journal Issue:||8||Source:||Medicine (United States)||Abstract:||
Rationale: Rare uterine choriocarcinoma can be differentiated gestational from nongestational choriocarcinoma by using short tandem repeats (STRs). Patient concerns: A 56-year-old Taiwanese woman underwent staging surgery because of suspicion of high-grade endometrial cancer. The pathology-confirmed uterine tumor with syncytiotrophoblasts and decidual change of the endometrium was harvested. Diagnosis: Uterine nongestational choriocarcinoma. Interventions: The tumor specimen, the patient's blood, and her husband's blood were drawn for STRs analysis using polymerase chain reaction amplification kit. The genotype of the tumor cells was solely maternal and made the diagnosis of uterine nongestational choriocarcinoma. Outcome: Adjuvant chemotherapy with etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine regimen achieved good response in the patient. The patient is now recurrence-free for 12months. Lessons: STRs aid precise classification of rare choriocarcinoma. We encourage using the method to analyze suspicious choriocarcinoma. ? 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/453016||DOI:||10.1097/MD.0000000000009899||SDG/Keyword:||3beta hydroxy delta5 steroid dehydrogenase; amelogenin; chorionic gonadotropin; cyclophosphamide; dactinomycin; etoposide; methotrexate; steroid delta isomerase; vincristine; antineoplastic agent; microsatellite DNA; adjuvant chemotherapy; adult; Article; blood analysis; blood sampling; cancer combination chemotherapy; cancer staging; case report; choriocarcinoma; clinical article; computer assisted tomography; cytology; decidua; decidualization; DNA extraction; Doppler ultrasonography; endometrium; endometrium biopsy; endometrium cancer; endometrium hyperplasia; female; follow up; genotype; gestational age; hormone substitution; human; human tissue; hysterectomy; immunochemistry; induced abortion; lymph node dissection; lymphadenopathy; medical history; menopause; microscopy; middle aged; multiple cycle treatment; multiplex polymerase chain reaction; myometrium; pelvic examination; pelvis lymph node; polymerase chain reaction; postmenopause; pregnancy; priority journal; recurrence free survival; risk factor; salpingooophorectomy; short tandem repeat; syncytiotrophoblast; Taiwanese; thorax radiography; transvaginal echography; treatment duration; treatment response; uterine nongestational choriocarcinoma; uterus blood flow; uterus cavity; uterus tumor; vagina bleeding; vaginal delivery; choriocarcinoma; genetics; pathology; procedures; uterus cancer; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Choriocarcinoma, Non-gestational; Female; Humans; Microsatellite Repeats; Middle Aged; Neoplasm Staging; Postmenopause; Uterine Neoplasms
|Appears in Collections:||法醫學科所|
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