https://scholars.lib.ntu.edu.tw/handle/123456789/454638
標題: | Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women | 作者: | Wu W.H. SHAO-CHUN LU Wang T.F. Jou H.J. Wang T.A. |
關鍵字: | Algae oil; Blood lipids; DHA; Hydroxyestrone; Oxidative stress; Postmenopausal vegetarian women | 公開日期: | 2006 | 卷: | 60 | 期: | 3 | 起(迄)頁: | 386-392 | 來源出版物: | European Journal of Clinical Nutrition | 摘要: | Background: Vegetarians are generally deficient in long-chain n-3 fatty acids. Long-chain n-3 fatty acids have a beneficial effect on plasma lipid levels, and some studies showed that they had breast cancer suppression effect. One of the biomarkers of breast cancer risk is the ratio of urinary 2-hydroxyestrone (2-OHE1) to 16α-hydroxyestrone (16α-OHE1). Objective: To investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) supplementation on blood lipids, estrogen metabolism and oxidative stress in vegetarians. Design: Single-blind, randomized, placebo-controlled trial. Interventions: Twenty-seven postmenopausal vegetarian women were recruited. After a 2-week run-in period with 6 g placebo corn oil, the subjects were subsequently randomized to receive either 6 g corn oil (n = 13) or 6 g DHA-rich algae oil (2.14 g of DHA/day) (n = 14) for 6 weeks. Two subjects in corn oil group withdrew before completion. Main outcome measures: Plasma lipids, urinary 2-OHE1 and 16α-OHE1, urinary F2-isoprostanes and plasma α-tocopherol. Results: Plasma LDL-DHA and EPA level increased significantly by DHA supplementation. DHA decreased plasma cholesterol (C) levels (P=0.04), but did not influence the levels of plasma TG, LDL-C and HDL-C, α-tocopherol, urinary F2-isoprostanes, 2-OHE1, 16α-OHE1 and ratio of 2-OHE1 to 16α-OHE1 as compared to corn oil. Conclusion: DHA supplementation at a dose of 2.14-g/day for 42 days decreases plasma cholesterol but neither does it show beneficial effects on estrogen metabolism, nor does it induce deleterious effects on the observed in vivo antioxidant or oxidative stress marker in postmenopausal vegetarian women. ? 2006 Nature Publishing Group. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644824147&doi=10.1038%2fsj.ejcn.1602328&partnerID=40&md5=e41c8b224adeaab9642340e0447417c6 https://scholars.lib.ntu.edu.tw/handle/123456789/454638 |
ISSN: | 0954-3007 | DOI: | 10.1038/sj.ejcn.1602328 | SDG/關鍵字: | alpha tocopherol; biological marker; corn oil; docosahexaenoic acid; estrogen derivative; high density lipoprotein cholesterol; icosapentaenoic acid; isoprostane derivative; lipid; low density lipoprotein cholesterol; placebo; adult; alga; article; clinical trial; controlled clinical trial; controlled study; diet supplementation; drug effect; estrogen metabolism; estrogen urine level; female; human; in vivo study; lipid blood level; oxidative stress; postmenopause; randomized controlled trial; single blind procedure; treatment duration; treatment withdrawal; vegetarian; vegetarian diet; vitamin blood level; Algae; alpha-Tocopherol; Biological Markers; Diet, Vegetarian; Dietary Supplements; Docosahexaenoic Acids; Estrogens; F2-Isoprostanes; Female; Humans; Hydroxyestrones; Lipids; Middle Aged; Oxidative Stress; Postmenopause; Single-Blind Method; algae; Zea mays |
顯示於: | 生物化學暨分子生物學科研究所 |
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