https://scholars.lib.ntu.edu.tw/handle/123456789/454884
標題: | Differences between methicillin-resistant Staphylococcus aureus bacteremic isolates harboring type IV and type v staphylococcal cassette chromosome mec genes based on prior patient healthcare exposure | 作者: | SHEY-YING CHEN Wang J.-L. Chen, Tony Hsiu Hsi WEN-CHU CHIANG JANN-TAY WANG SHYR-CHYR CHEN SHAN-CHWEN CHANG PO-REN HSUEH |
公開日期: | 2010 | 卷: | 29 | 期: | 12 | 起(迄)頁: | 1539-1546 | 來源出版物: | European Journal of Clinical Microbiology and Infectious Diseases | 摘要: | This observational study enrolled adult patients with bacteremia due to methicillin-resistant Staphylococcus aureus (MRSA) who were treated at the emergency department of a teaching hospital from 2001 to 2007. MRSA isolates with type IV and type V staphylococcal cassette chromosome mec (SCCmec) genes (SCC IV/V-MRSA) were included in the final analysis. Healthcare-associated SCC IV/V-MRSA (HA-SCC IV/V-MRSA) and community-acquired SCC IV/V-MRSA (CA-SCC IV/V-MRSA) were defined as the identification of an SCC IV/V-MRSA isolate from a patient with and without healthcare-associated risk factors, respectively. Thirty-four cases of CA-SCC IV/V-MRSA (20 SCCmec type IV, 14 SCCmec type V) and 81 cases of HA-SCC IV/V-MRSA (59 SCCmec type IV, 22 SCCmec type V) bacteremia were identified. Vascular device-associated infections were a significant infection source in HA-SCC IV/V-MRSA bacteremia cases. SCCmec type IV HA-SCC IV/V-MRSA isolates (3.4%) were significantly less likely to carry the Panton-Valentine leukocidin (PVL) gene than SCCmec type IV CA-SCC IV/V-MRSA isolates (35.0%, p = 0.001). The 90-day cumulative probability of survival was 76% for patients with CA-SCC IV/V-MRSA bacteremia and 66% for patients with HA-SCC IV/V-MRSA bacteremia (p = 0.247, by the Wilcoxon rank-sum test). Significant differences in antimicrobial susceptibility were observed between bacterial isolates from patients with CA-SCC IV/V-MRSA bacteremia and HA-SCC IV/V-MRSA bacteremia. ? 2010 Springer-Verlag. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/454884 | DOI: | 10.1007/s10096-010-1038-4 | SDG/關鍵字: | Panton Valentine leukocidin; adolescent; adult; antibiotic sensitivity; article; bacterial chromosome; bacterial gene; bacterium identification; bacterium isolate; community; community acquired methicillin resistant staphylococcus aureus; comparative study; controlled study; device infection; emergency ward; human; major clinical study; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; multilocus sequence typing; nonhuman; priority journal; risk factor; soft tissue infection; staphylococcal cassette chromosome mec type IV; staphylococcal cassette chromosome mec type V; survival rate; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Chromosomes, Bacterial; Community-Acquired Infections; Cross Infection; Female; Hospitals, University; Humans; Male; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Risk Factors; Staphylococcal Infections; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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