https://scholars.lib.ntu.edu.tw/handle/123456789/454903
標題: | Predictive model of antimicrobial-resistant Gram-negative bacteremia at the ED | 作者: | WEN-CHU CHIANG SHEY-YING CHEN KUO-LIONG CHIEN Hui-Min G. Ming-Fang Yen A. Su C.-P. CHIEN-CHANG LEE YEE-CHUN CHEN SHAN-CHWEN CHANG SHYR-CHYR CHEN WEN-JONE CHEN Chen, Tony Hsiu Hsi |
公開日期: | 2007 | 卷: | 25 | 期: | 6 | 起(迄)頁: | 597-607 | 來源出版物: | American Journal of Emergency Medicine | 摘要: | Background: Despite numerous studies identifying the risk factors related to Gram-negative antimicrobial resistance, an epidemiological model to reliably predict antimicrobial Gram-negative resistance in clinics, before the bacterial culture result is available, has not yet been developed. Objectives: The aim of this study was to develop a predictive model to assist physicians in selecting appropriate antimicrobial agents before the details of the microbiology and drug susceptibility are known. Materials and Methods: A prospective study was conducted between June 1, 2001, and May 31, 2002, at the emergency department (ED) of National Taiwan University Hospital. Enrollees were patients with Gram-negative bacteremia (GNB) at ED. Other information collected included demographic characteristics, underlying comorbidities, hospital exposure and health care-associated factors, and details of initial presentation. Two primary outcomes were defined, including cefazolin-resistant (CZ-RES) GNB and ceftriaxone-resistant (CTX-RES) GNB. Two thirds of the data was randomly allocated to a derivation data set (for developing predictive models), and the rest, to a validation data set (for testing model validity). Simplified models, using a coefficient-based scoring method, were also developed for clinical applications. Results: Based on 695 episodes of GNB, predictors of CZ-RES GNB were time since last hospitalization (increased risk for durations <1 month), prior infection with a CTX-RES strain, post-transplantation immunosuppressant use, residence in a nursing home or history of stroke with repeated choking, and poor oxygen saturation (<95%) at admission to ED. Cirrhosis showed a protective effect by reducing the odds of antimicrobial-resistant GNB. The area under receiver operating characteristic (ROC) curve for the CZ-RES model was 0.76 (95% confidence interval, 0.71-0.81). The CTX-RES model included all the variables that were in the CZ-RES model plus abnormal leukocyte count (<1000 or >15 000 /mm3) at entry to ED. In this case, however, previous hospitalization within the last 2 weeks was a key factor. The area under this ROC curve was 0.82 (95% confidence interval, 0.76-0.88). There was lacking of difference in the area under the ROC curve between the 2 final (simplified) models either based on the derivation or validation data sets. Conclusion: We have developed 2 models for predicting risk of antimicrobial Gram-negative infection by identifying and quantifying associated risk factors. These models could be used by physicians to determine the most appropriate choice of antibiotic for first-line therapy, particularly in situations where the culture result is not yet known. ? 2007 Elsevier Inc. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/454903 | DOI: | 10.1016/j.ajem.2006.11.024 | SDG/關鍵字: | antiinfective agent; cefazolin; ceftriaxone; immunosuppressive agent; steroid; vancomycin; adult; aged; article; blood culture; comorbidity; controlled study; drug sensitivity; emergency ward; female; Gram negative sepsis; high risk patient; hospitalization; human; leukocyte count; liver cirrhosis; major clinical study; male; microbiological examination; oxygen saturation; priority journal; scoring system; stroke; Adult; Aged; Analysis of Variance; Anti-Infective Agents; Bacteremia; Cephalosporins; Decision Support Techniques; Drug Resistance, Microbial; Emergency Service, Hospital; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; ROC Curve |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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