https://scholars.lib.ntu.edu.tw/handle/123456789/455315
標題: | Development and Characterization of Magnetic Bioceramic Nanocrystals for Intracellular Hyperthermia | 作者: | Wu H.C. Lin J.Y. Hsieh S.Y. Wang T.W. JUI-SHENG SUN |
公開日期: | 2015 | 出版社: | Springer Verlag | 卷: | 47 | 起(迄)頁: | 5-7 | 來源出版物: | IFMBE Proceedings | 摘要: | Hyperthermia for the treatment of resistant tumors has been reported with promising results. Repeated treatment times and applicable for many kinds of cancers are the potential benefits of hyperthermia. Of note is that the success of intracellular hyperthermia is largely dependent on the development of an adequate heat mediator. In this work, we have successfully developed an intracellular hyperthermia system using magnetic hydroxyapatite (mHap) nanocrystals as a thermoseed. After surface modification, poly (ethylene glycol) (PEG) and hyaluronic acid (HA) modified mHap nanocrystals could not only be localized and accumulated in cancer cells, but also efficiently taken up by targeted tumor cells via HA receptor mediated endocytosis process. Furthermore, these Hap-based magnetic nanocrystals may also serve as a tracer for the diagnostic contrast agent under MRI and a drug delivery carrier for therapeutic applications in cancer therapy in vitro and in vivo. ? Springer International Publishing Switzerland 2015. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84914814296&doi=10.1007%2f978-3-319-11128-5_2&partnerID=40&md5=bed293198616d8afb91391a09a6110da https://scholars.lib.ntu.edu.tw/handle/123456789/455315 |
ISSN: | 1680-0737 | DOI: | 10.1007/978-3-319-11128-5_2 | SDG/關鍵字: | Biochemical engineering; Biomedical engineering; Diagnosis; Diseases; Drug delivery; Hyaluronic acid; Molecular biology; Nanocrystals; Polyethylene glycols; Surface treatment; Tumors; Contrast agent; Drug delivery carrier; Hyperthermia; Hyperthermia systems; Magnetic nanocrystals; Potential benefits; Receptor-mediated endocytosis; Therapeutic Application; Hyperthermia therapy |
顯示於: | 醫學系 |
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