The fabrication and characterization of dicalcium phosphate dihydrate-modified magnetic nanoparticles and their performance in hyperthermia processes in vitro
Journal
Biomaterials
Journal Volume
30
Journal Issue
27
Pages
4700-4707
Date Issued
2009
Author(s)
Abstract
Many different types of magnetic particles have been developed for the purpose of hyperthermia cancer therapy. In this study, a magnetic nanoparticle based on dicalcium phosphate dihydrate (DCPD) was formed by co-precipitation method. Addition of different concentrations of ferrous chloride to DCPD can alter its material properties. Various physical, chemical and magnetic tests of the magnetic DCPD nanoparticles (mDCPD) were performed, including X-ray diffraction (XRD), inductively coupled plasma-optical emission spectrometer (ICP-OES), superconducting quantum interference device (SQUID), and transmission electron microscopy (TEM). The heating efficiency of mDCPD in alternating magnetic field was proved to be suitable for hyperthermia. The results of cytotoxicity tests (WST-1 and LDH assay) showed no harmful effect. The mDCPD showed relative cancer-killing ability without damaging normal cells in vitro. ? 2009 Elsevier Ltd. All rights reserved.
SDGs
Other Subjects
Alternating magnetic field; Brushite; Coprecipitation method; Cytotoxicity test; Dicalcium phosphate dihydrate; Ferrous chloride; Harmful effects; Heating efficiencies; Hyperthermia cancer; ICP-OES; In vitro test; In-vitro; LDH assay; Magnetic nanoparticles; Magnetic particle; Material property; Optical emission spectrometer; Superconducting quantum interference device; TEM; Calcium; Calcium alloys; Chlorine compounds; Electromagnetic field effects; Hyperthermia therapy; Inductively coupled plasma; Magnetic fields; Magnetic materials; Nanocomposites; Nanoparticles; Optical microscopy; Phosphates; Precipitation (chemical); SQUIDs; Superconducting magnets; Testing; Transmission electron microscopy; X ray diffraction; Calcium phosphate; calcium phosphate dibasic; ferrous chloride; lactate dehydrogenase; nanoparticle; animal cell; article; controlled study; heating; human; human cell; hyperthermic therapy; in vitro study; lung carcinoma; lung fibroblast; magnetic field; mouse; nanofabrication; nonhuman; precipitation; priority journal; therapy effect; Animals; Biological Assay; Calcium Phosphates; Cell Death; Cell Line, Tumor; Humans; L-Lactate Dehydrogenase; Magnetics; Mice; Mitochondria; Nanoparticles; Neoplasms; Particle Size; Spectrophotometry, Atomic; Temperature; Tetrazolium Salts; Time Factors; X-Ray Diffraction
Type
journal article