https://scholars.lib.ntu.edu.tw/handle/123456789/456970| Title: | Functions of DNA methyltransferase 3-like in germ cells and beyond | Authors: | Liao H.-F. Tai K.-Y. Chen W.S.-C. Cheng L.C. HONG-NERNG HO Lin S.-P. SHAU-PING LIN |
Issue Date: | 2012 | Journal Volume: | 104 | Journal Issue: | 10 | Start page/Pages: | 571-587 | Source: | Biology of the Cell | Abstract: | DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research. ? 2012 So?i?t? Francaise des Microscopies and Soci?t? de Biologie Cellulaire de France. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/456970 | ISSN: | 02484900 | DOI: | 10.1111/boc.201100109 | SDG/Keyword: | DNA methyltransferase 3A; DNA methyltransferase 3B; DNA methyltransferase 3L; unclassified drug; untranslated RNA; chromatin; DNA methylation; embryonic stem cell; enzyme activity; epigenetics; gene expression; germ cell; knockout mouse; nonhuman; oocyte; preimplantation embryo; priority journal; protein function; retroposon; review; spermatid; spermatocyte; spermatogonium; Animals; DNA (Cytosine-5-)-Methyltransferase; DNA Methylation; Epigenesis, Genetic; Genome; Genomic Imprinting; Germ Cells; Histone Deacetylases; Histones; Humans; Mice; Neoplasms; Retroelements; Stem Cells [SDGs]SDG3 |
| Appears in Collections: | 生物科技研究所 |
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