|Title:||Functions of DNA methyltransferase 3-like in germ cells and beyond||Authors:||Liao H.-F.
|Issue Date:||2012||Journal Volume:||104||Journal Issue:||10||Start page/Pages:||571-587||Source:||Biology of the Cell||Abstract:||
DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research. ? 2012 So?i?t? Francaise des Microscopies and Soci?t? de Biologie Cellulaire de France.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/456970||ISSN:||02484900||DOI:||10.1111/boc.201100109||SDG/Keyword:||DNA methyltransferase 3A; DNA methyltransferase 3B; DNA methyltransferase 3L; unclassified drug; untranslated RNA; chromatin; DNA methylation; embryonic stem cell; enzyme activity; epigenetics; gene expression; germ cell; knockout mouse; nonhuman; oocyte; preimplantation embryo; priority journal; protein function; retroposon; review; spermatid; spermatocyte; spermatogonium; Animals; DNA (Cytosine-5-)-Methyltransferase; DNA Methylation; Epigenesis, Genetic; Genome; Genomic Imprinting; Germ Cells; Histone Deacetylases; Histones; Humans; Mice; Neoplasms; Retroelements; Stem Cells
|Appears in Collections:||生物科技研究所|
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