https://scholars.lib.ntu.edu.tw/handle/123456789/458231
標題: | Impact of interleukin-8 gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan | 作者: | Liu C.-M Yeh C.-J Yu C.-C Chou M.-Y Lin C.-H LING-HUNG WEI Lin C.-W Yang S.-F Chien M.-H. |
關鍵字: | IL-8; Oral cancer; Polymorphism | 公開日期: | 2012 | 卷: | 18 | 期: | 3 | 起(迄)頁: | 307-314 | 來源出版物: | Oral Diseases | 摘要: | Objectives: Interleukin-8 (IL-8), which is an angiogenic chemokine with a high expression level in tumor tissues, plays important roles in developing many human malignancies including oral squamous cell carcinoma (OSCC). This study was designed to examine the association of IL-8 gene polymorphisms with the susceptibility and clinicopathological characteristics of OSCC. Methods: A total of 270 patients with OSCC and 350 healthy control subjects were recruited. Four single nucleotide polymorphisms (SNPs) of IL-8 genes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping analysis. Results: Results showed that four IL-8 SNPs (-251 T/A, +781 C/T, +1633 C/T, and +2767 A/T) were not associated with oral cancer susceptibility as well as clinicopathological parameters. But among 345 smokers, IL-8 polymorphisms carriers with betel quid chewing were found to have a 17.41- to 23.14-fold risk to have oral cancer compared to IL-8 wild-type carriers without betel quid chewing. Among 262 betel quid chewers, IL-8 polymorphisms carriers with smoking have a 10.54- to 20.44-fold risk to have oral cancer compared to those who carried wild type without smoking. Conclusions: Our results suggest that the combination of IL-8 gene polymorphisms and environmental carcinogens might be highly related to the risk of oral cancer. ? 2011 John Wiley & Sons A/S. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/458231 | ISSN: | 1354-523X | DOI: | 10.1111/j.1601-0825.2011.01882.x | SDG/關鍵字: | interleukin 8; 3' untranslated region; adult; article; cancer staging; cancer susceptibility; case control study; controlled study; environmental factor; female; genetic analysis; genetic association; genotype; heterozygote; human; major clinical study; male; mastication; mouth carcinoma; mouth squamous cell carcinoma; polymerase chain reaction; priority journal; promoter region; restriction fragment length polymorphism; single nucleotide polymorphism; smoking; squamous cell carcinoma; Taiwan; 3' Untranslated Regions; Adenine; Areca; Carcinogens; Carcinoma, Squamous Cell; Case-Control Studies; Cytosine; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-8; Introns; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Neovascularization, Pathologic; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Factors; Smoking; Thymine |
顯示於: | 醫學系 |
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