Relationship of interleukin-8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development
Journal
Journal of Surgical Oncology
Journal Volume
104
Journal Issue
7
Pages
798-803
Date Issued
2011
Author(s)
Abstract
Background and Objectives Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide, and the second leading cause of death from cancer in Taiwan. Interleukin-8 (IL-8) is an angiogenic chemokine with important roles in the development and progression of many human malignancies including HCC. This study investigates the effects of single-nucleotide polymorphisms (SNPs) in the IL-8 gene on the susceptibility and clinicopathological characteristics of HCC. Methods One hundred thirty-one HCC patients and 340 control subjects were analyzed for four IL-8 SNPs (-251 T/A, +781 C/T, +1633 C/T, and +2767 A/T) using PCR-RFLP genotyping analysis. Results After adjusting for other confounders, results show that individuals with the IL-8 +781 T/T polymorphic genotype had a significantly lower risk of developing HCC than those with the wild-type (C/C) genotype (AOR = 0.346; 95% CI: 0.132-0.909). Multiple regression analysis showed that the presence of T/A or A/A at IL-8 -251 may indicate higher potential risk of hepatitis B infection (AOR = 2.847; 95% CI: 1.083-8.656). Additionally, these four IL-8 SNPs did not associate with liver-related clinicopathological markers in serum. Conclusions Genetic polymorphism at IL-8 +781 is an important factor in determining susceptibility to HCC in the Taiwanese population. J. Surg. Oncol. 2011; 104:798-803. ? 2011 Wiley Periodicals, Inc. Copyright ? 2011 Wiley Periodicals, Inc.
Subjects
genetic polymorphism; hepatocellular carcinoma; interleukin-8
SDGs
Other Subjects
interleukin 8; adult; article; cancer risk; cancer susceptibility; case control study; controlled study; female; gene mutation; genetic analysis; genotype; human; liver cell carcinoma; major clinical study; male; polymerase chain reaction; priority journal; restriction fragment length polymorphism; single nucleotide polymorphism; Asian Continental Ancestry Group; Carcinoma, Hepatocellular; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Interleukin-8; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Retrospective Studies; Taiwan
Type
journal article