https://scholars.lib.ntu.edu.tw/handle/123456789/458250
標題: | A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth | 作者: | Su J.-L Lai K.-P CHI-AN CHEN CHING-YAO YANG Chen P.-S Chang C.-C Chou C.-H Hu C.-L Kuo M.-L CHANG-YAO HSIEH LING-HUNG WEI |
公開日期: | 2005 | 卷: | 65 | 期: | 11 | 起(迄)頁: | 4827-4835 | 來源出版物: | Cancer Research | 摘要: | Experimental and clinical findings support the essential role of interleukin (IL)-6 in the pathogenesis of various human cancers and provide a rationale for targeted therapeutic investigations. A novel peptide, S7, which selectively binds to IL-6 receptor (IL-6R) α chain (gp80) and broadly inhibits IL-6-mediated events, was identified using phage display library screening. The synthetic S7 peptide specifically bound to soluble IL-6R as well as cognate human IL-6Rα, resulting in a dose-dependent blockade of the interaction between IL-6 and IL-6Rα. S7 peptide prevents IL-6-mediated survival signaling and sensitizes cervical cancer cells to chemotherapeutic compounds in vitro. The in vitro analysis of antiangiogenic activity showed that S7 peptide substantially inhibits IL-6-induced vascular endothelial growth factor-A expression and angiogenesis in different cancer cell lines. Furthermore, S7 peptide was bioavailable in vivo, leading to a significant suppression of IL-6-induced vascular endothelial growth factor-mediated cervical tumor growth in severe combined immunodeficient mice. These observations show the feasibility of targeting IL-6/IL-6R interaction using the small peptide and highlight its potential in the clinical applications. ? 2005 American Association for Cancer Research. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/458250 | ISSN: | 0008-5472 | DOI: | 10.1158/0008-5472.CAN-05-0188 | SDG/關鍵字: | interleukin 6; interleukin 6 receptor; nuclear protein; protein S6; synthetic peptide; vasculotropin A; alpha chain; angiogenesis; article; bioavailability; cancer cell; cancer survival; chemotherapy; combined immunodeficiency; controlled study; human; human cell; in vitro study; in vivo study; mouse; nonhuman; phage display; priority journal; protein binding; tumor growth; uterine cervix cancer |
顯示於: | 醫學系 |
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