Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle
Journal
Molecules
Journal Volume
15
Journal Issue
10
Pages
7115-7124
Date Issued
2010
Author(s)
Abstract
Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
Type
journal article