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  4. Decidual Natural Killer Cytotoxicity Decreased in Normal Pregnancy but Not in Anembryonic Pregnancy and Recurrent Spontaneous Abortion
 
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Decidual Natural Killer Cytotoxicity Decreased in Normal Pregnancy but Not in Anembryonic Pregnancy and Recurrent Spontaneous Abortion

Journal
American Journal of Reproductive Immunology
Journal Volume
34
Journal Issue
5
Pages
274-280
Date Issued
1995
Author(s)
KUANG-HAN CHAO  
YU-SHIH YANG  
HONG-NERNG HO  
SHEE-UAN CHEN  
HSIN-FU CHEN 
DAI H. J
HUANG S. C
GILL T.J 3rd
DOI
10.1111/j.1600-0897.1995.tb00953.x
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/459889
Abstract
PROBLEM: The natural killer (NK) cell activity is depressed in the decidua of early normal pregnancy. Recently Morii et al. (Am J Reprod Immunol 1993;29:1–4) found that all early intradecidual CD3+ T cells expressed either T cell receptor (TCR) α/β or γ/δ but that the expression of the CD3+/TCR complex was down?regulated. METHOD: To test whether these changes in decidual cellular immunity are different among normal pregnancy, anembryonic pregnancy and recurrent spontaneous abortion, we examined the immune cell subpopulations in the decidua from these three types of pregnancy using flow cytometry and an NK cytotoxicity assay. RESULTS: Intradecidual CD3+ T cells expressed either TCR α/β or γ/δ, and the level of expression of the CD3/TCR complex was down?regulated in normal pregnancy, anembryonic pregnancy, and recurrent spontaneous abortion. Although the relative proportion of decidual NK cells was increased to approximately the same extent in all three types of pregnancy, decidual NK activity was higher in anembryonic pregnancies and in recurrent spontaneous abortions than it was in normal pregnancies. CONCLUSION: Decidual NK cell responses are different in anembryonic pregnancies and in recurrent spontaneous abortions than in normal pregnancies. Whether this difference is pathogenic or is the response to a dead embryo remains to be elucidated. 1995 Munksgaard
SDGs

[SDGs]SDG3

Other Subjects
cd3 antigen; t lymphocyte receptor; article; cell activity; cell mediated cytotoxicity; cellular immunity; clinical article; controlled study; decidua; embryo mortality; female; flow cytometry; human; human tissue; immunocompetent cell; natural killer cell; pregnancy; priority journal; spontaneous abortion; Abortion, Habitual; Abortion, Spontaneous; Cytotoxicity, Immunologic; Decidua; Female; Fetal Death; Human; Killer Cells, Natural; Pregnancy; Pregnancy, Ectopic; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Support, Non-U.S. Gov't
Type
journal article

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