https://scholars.lib.ntu.edu.tw/handle/123456789/459930
標題: | The role of cytokines in endometriosis | 作者: | MING-YIH WU HONG-NERNG HO |
公開日期: | 2003 | 卷: | 49 | 期: | 5 | 起(迄)頁: | 285-296 | 來源出版物: | American Journal of Reproductive Immunology | 摘要: | Problem: To review the literature on the role of peritoneal cytokines in the pathogenesis and endometriosis-related infertility. Methods of study: A MEDLINE search was conducted by the key words of cytokine and endometriosis in the English publications, and references identified within the identified papers were also reviewed. Results: Several cytokines including interleukin (IL)-l, 6, 8, 10, tumor necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF) were reported to be increased in the peritoneal fluid (PF) of women with endometriosis. Those cytokines may be involved in macrophage activation, inflammatory change and enhanced angiogenesis. However, some cytokines were less expressed such as IL-2, and interferon (IFN)-γ. They reflect the impaired T- and natural killer (NK)-cell function. Endometriotic implants produce some factors, e.g. matrix metalloproteinases (MMPs), Bcl-2, and affect their capacity to implant into the peritoneum. Conclusion: Peritoneal cytokines, which are produced by mesothelial cells, leukocytes and ectopic endometrial cells, interwork locally and systemically in women with endometriosis. More studies about the specific role and interactions of these cytokines are needed to improve the understanding of endometriosis and to develop novel therapies. ? Blackwell Munksgaard, 2003. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/459930 | ISSN: | 8755-8920 | DOI: | 10.1034/j.1600-0897.2003.01207.x | SDG/關鍵字: | antioxidant; cytokine; epidermal growth factor; fibroblast growth factor; gamma interferon; gelatinase A; intercellular adhesion molecule 1; interleukin 1; interleukin 10; interleukin 12; interleukin 13; interleukin 1beta; interleukin 2; interleukin 4; interleukin 5; interleukin 6; interleukin 8; interleukin 9; matrix metalloproteinase; nitric oxide synthase; platelet derived endothelial cell growth factor; protein Bax; protein bcl 2; reactive oxygen metabolite; somatomedin; tissue inhibitor of metalloproteinase 1; transforming growth factor beta1; tumor necrosis factor alpha; unindexed drug; vasculotropin; angiogenesis; cell adhesion; cell function; cell infiltration; disease association; disease course; endometriosis; endometrium cell; female; female infertility; human; implantation; inflammation; leukocyte; macrophage activation; MEDLINE; menstruation; mesothelium cell; natural killer cell; nonhuman; pathogenesis; peritoneal fluid; peritoneal fluid level; priority journal; protein expression; protein interaction; review; T lymphocyte; Cell Adhesion; Cytokines; Endometriosis; Female; Humans; Infertility, Female; Neovascularization, Pathologic |
顯示於: | 醫學系 |
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