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  4. The suppression of peritoneal cellular immunity in women with endometriosis could be restored after gonadotropin releasing hormone agonist treatment
 
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The suppression of peritoneal cellular immunity in women with endometriosis could be restored after gonadotropin releasing hormone agonist treatment

Journal
American Journal of Reproductive Immunology
Journal Volume
35
Journal Issue
6
Pages
510-516
Date Issued
1996
Author(s)
MING-YIH WU  
KUANG-HAN CHAO  
SHEE-UAN CHEN  
HSIN-FU CHEN 
YU-SHIH YANG  
Huang S.-C
HONG-NERNG HO  
DOI
10.1111/j.1600-0897.1996.tb00050.x
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/459965
Abstract
Problem: Our previous study reported that peritoneal natural killer (NK) cytotoxicity and CD3+CD25+ lymphocyte subpopulation were suppressed in women with advanced endometriosis. Whether these phenomena are general for all stages of endometriosis and whether these alterations could be restored by long-term use of gonadotropin releasing hormone agonist (GnRHa) are further tested in this study. Method: Lymphocyte subpopulations (B cells, NK cells, T cells, and T-cell activation markers such as CD69, HLA-DR, and CD25) and NK cell cytotoxicity of peripheral blood and peritoneal fluid by dual-color flow cytometry and 51Cr release assay in 30 cases of endometriosis were compared with those in 26 controls. We also compared these changes before and after 6-month treatment with GnRHa for advanced endometriosis. Results: Compared with the controls, only those women with advanced endometriosis showed lower NK cytotoxicity in peritoneal fluid mononuclear cells (PFMC). The CD3+CD69+ lymphocyte subpopulation decreased in peripheral blood mononuclear cells (PBMC) of advanced endometriosis, while the CD3+CD25+ lymphocyte subpopulation decreased in both PBMC and PFMC of mild and advanced endometriosis. After GnRHa treatment, the CD3+CD69+ lymphocyte subpopulation increased in both PBMC and PFMC and the CD3+CD25+ lymphocyte subpopulation increased in PFMC, but not in PBMC. Conclusion: Impaired local immunological function in the PF of endometriosis was confirmed by this study and the impairments could be restored after long-term GnRHa therapy.
SDGs

[SDGs]SDG3

Other Subjects
CD3 antigen; CD69 antigen; chromium 51; gonadorelin agonist; HLA DR antigen; interleukin 2 receptor; leuprorelin; article; B lymphocyte; cell mediated cytotoxicity; cellular immunity; cellular immunodeficiency; clinical article; controlled study; disease severity; endometriosis; female; flow cytometry; human; human cell; lymphocyte subpopulation; mononuclear cell; natural killer cell; peritoneal fluid; priority journal; subcutaneous drug administration; T lymphocyte activation
Type
journal article

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