https://scholars.lib.ntu.edu.tw/handle/123456789/46002
標題: | Revision of the Absolute Configuration at C(23) of Lanostanoids and Isolation of Secondary Metabolites from Formosan Soft Coral Nephthea erecta | 作者: | Cheng, Shi-Yie Wen, Zhi-Hong Wang, Shang-Kewi Chiang, Michael Y. El-Gamal, Ali A. H. CHANG-FENG DAI Duh, Chang-Yih |
公開日期: | 2009 | 卷: | 6 | 期: | 1 | 起(迄)頁: | 86-95 | 來源出版物: | Chemistry and Biodiversity | 摘要: | Three new oxygenated ergostanoids, 1-3, one known ergostanoid, 4, one new trinoreudesmadienone, 5, one new calamenene type sesquiterpene, 6, and one known aristolane-type sesquiterpene, (-)-aristolone (7), have been isolated from the AcOEt extract of the soft coral Nephthea erecta. The structures of these compounds were determined by extensive spectroscopic and X-ray crystallographic analysis, as well as Mosher's method. We revised the absolute configuration at C(23) in the side chain of some lanostanoids as a result of the Mosher's products of 1 (i.e., 1a and 1b). The cytotoxicities against selected cancer cells and the anti-inflammatory effects of these tested metabolites 1-7 were determined in vitro. ? 2009 Verlag Helvetica Chimica Acta AG, Z?rich. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-63049129348&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/348442 http://ntur.lib.ntu.edu.tw/bitstream/246246/174479/1/96.pdf |
DOI: | 10.1002/cbdv.200800015 | SDG/關鍵字: | 3beta,22 ergosta 5,24(28) diene 3,17,22 triol; 3beta,23 ergosta 5,24(28) diene 3,23 diol; 5,6,7,8 tetrahydro 4alpha,8 dimethylnaphthalen 2(4alpha h) one; 5,6,7,8 tetrahydro 5 methyl 8 (1 methylethyl)naphthalene 2 carbaldehyde; aristolone; ergostanoid derivative; lanostanoid derivative; natural product; Nephthea erecta extract; sesquiterpene derivative; trinoreudesmadienone; unclassified drug; drug derivative; lanostanoid; lanosterol; animal cell; antiinflammatory activity; article; controlled study; coral; drug cytotoxicity; drug isolation; drug screening; drug structure; electrospray mass spectrometry; human; human cell; leukemia cell line; macrophage; mouse; Nephthea erecta; nonhuman; structure analysis; Taiwan; X ray crystallography; animal; Anthozoa; cell line; chemistry; isolation and purification; nuclear magnetic resonance spectroscopy; Alcyonacea; Nephthea; Animals; Anthozoa; Cell Line; Humans; Lanosterol; Magnetic Resonance Spectroscopy; Mice |
顯示於: | 海洋研究所 |
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