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  4. Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies
 
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Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies

Journal
Fertility and Sterility
Journal Volume
76
Journal Issue
4
Pages
797-803
Date Issued
2001
Author(s)
HONG-NERNG HO  
KUANG-HAN CHAO  
HSIN-FU CHEN 
SHEE-UAN CHEN  
MING-YIH WU  
YU-SHIH YANG  
DOI
10.1016/S0015-0282(01)01999-9
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/460111
Abstract
Objective: To examine whether maternal immune responses during normal pregnancy are Th2 biased and whether there are specific changes when anembryonic pregnancy occurs. Design: Prospective study. Setting: Department of Obstetrics and Gynecology at a university hospital. Patient(s): We studied 32 pregnant women receiving elective abortions of normal pregnancies and 35 women with anembryonic pregnancies between 6 weeks and 10 weeks of gestational age. Intervention(s): Using the multilabeling capability of three-color flow cytometry, it is possible to measure intracellular cytokines and cell surface markers simultaneously to determine which cells are the cytokine-producing cells. Main Outcome Measure(s): We examined the extent and proportion of mononuclear cells expressing specific T-cell surface markers and cytokines, interferon γ, and interleukin 4 in the peripheral blood and deciduae. Secreted cytokines in the supernatants after 24-hour culture were also compared. Result(s): During the unstimulated status, the proportion of IL-4-secreting cells significantly exceeded that of IFN-γ-secreting cells in the peripheral blood and decidua in normal pregnancies and was significantly decreased when anembryonic pregnancies occurred. Consequently, the Th1/Th2 ratios were increased during anembryonic pregnancies. However, after 24-hour culture, only another Th2-type cytokine, IL-10, was markedly increased and exceeded IFN-γ secretion in cultures from both the peripheral blood and decidua in normal pregnancies. Conclusion(s): The decidual T lymphocytes are Th2 predominant. When anembryonic pregnancy occurs, this Th2 predominance disappears. ? 2001 by American Society for Reproductive Medicine.
SDGs

[SDGs]SDG3

Other Subjects
cell surface marker; cytokine; gamma interferon; interleukin 10; interleukin 4; article; cell culture; cell population; cell secretion; cell specificity; cell surface; cellular distribution; clinical article; controlled study; cytokine production; decidua; embryo; female; flow cytometry; gestational age; human; human cell; immune response; mononuclear cell; pregnancy; priority journal; T lymphocyte; Th1 cell; Th2 cell; Cytokines; Decidua; Female; Fetal Death; Humans; Kinetics; Pregnancy; Prospective Studies; Reference Values; Th1 Cells; Th2 Cells
Type
journal article

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