https://scholars.lib.ntu.edu.tw/handle/123456789/460122
標題: | Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women | 作者: | JEHN-HSIAHN YANG CHIN-DER CHEN MING-YIH WU KUANG-HAN CHAO YU-SHIH YANG HONG-NERNG HO |
公開日期: | 2000 | 卷: | 74 | 期: | 2 | 起(迄)頁: | 261-267 | 來源出版物: | Fertility and Sterility | 摘要: | Objective: To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT). Design: Prospective study. Setting: University teaching hospital.Patient(s): Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group). Intervention(s): Continuous usage of E2 valerate 2 mg/d and medroxyprogesterone acetate 5 mg/d in postmenopausal women in the study group. Main Outcome Measure(s): Immunophenotyping with flow cytometry, cytokine production with and without mitogen stimulation of the peripheral mononuclear cells, and a natural killer (NK) cell cytotoxicity test against K562 target cells by the 51Cr-release assay were performed in the control group and in the study group before, 1 month after, and 6 months after HRT. Result(s): NK cytotoxicity, interferon-γ production, and the T-cell subpopulation were significantly decreased, and the subpopulations of CD3+CD25+ and CD3+HLA-DR+ were increased in the study group before HRT when compared with those in the control group. After HRT was given for 6 months, however, the NK cytotoxicity increased significantly in the postmenopausal women to a value similar to that of the control group. Conclusion(s): Women after menopause are prone to impaired immune responses. Nevertheless, some of the impairment can be restored after HRT. Copyright (C) 2000 American Society for Reproductive Medicine. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460122 | ISSN: | 0015-0282 | DOI: | 10.1016/S0015-0282(00)00622-1 | SDG/關鍵字: | estradiol; gamma interferon; medroxyprogesterone acetate; adult; article; cell mediated cytotoxicity; clinical article; clinical trial; controlled clinical trial; controlled study; female; hormone substitution; human; human cell; immune deficiency; natural killer cell; postmenopause; priority journal; T lymphocyte subpopulation; Adult; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Hormone Replacement Therapy; Humans; Interferon Type II; Interleukin-2; Interleukin-5; Killer Cells, Natural; Middle Aged; Postmenopause; Prospective Studies; T-Lymphocytes |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。