Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis
Journal
American Journal of Obstetrics and Gynecology
Journal Volume
175
Journal Issue
5
Pages
1236-1241
Date Issued
1996
Author(s)
Abstract
OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1β interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-α were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin- 1β interleukin-6, and tumor necrosis factor-α and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.
SDGs
Other Subjects
gamma interferon; gonadorelin agonist; interleukin 1beta; interleukin 2; interleukin 6; tumor necrosis factor alpha; adult; article; cell proliferation; clinical article; controlled study; endometriosis; female; human; human cell; immune deficiency; immunomodulation; interferon production; peritoneal fluid; priority journal; T lymphocyte; T lymphocyte activation
Type
journal article