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  4. Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis
 
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Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis

Journal
American Journal of Obstetrics and Gynecology
Journal Volume
175
Journal Issue
5
Pages
1236-1241
Date Issued
1996
Author(s)
HONG-NERNG HO  
MING-YIH WU  
KUANG-HAN CHAO  
CHIN-DER CHEN  
SHEE-UAN CHEN  
HSIN-FU CHEN 
YU-SHIH YANG  
DOI
10.1016/S0002-9378(96)70034-0
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/460169
Abstract
OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1β interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-α were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin- 1β interleukin-6, and tumor necrosis factor-α and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.
SDGs

[SDGs]SDG3

Other Subjects
gamma interferon; gonadorelin agonist; interleukin 1beta; interleukin 2; interleukin 6; tumor necrosis factor alpha; adult; article; cell proliferation; clinical article; controlled study; endometriosis; female; human; human cell; immune deficiency; immunomodulation; interferon production; peritoneal fluid; priority journal; T lymphocyte; T lymphocyte activation
Type
journal article

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