https://scholars.lib.ntu.edu.tw/handle/123456789/460169
Title: | Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis | Authors: | HONG-NERNG HO MING-YIH WU KUANG-HAN CHAO CHIN-DER CHEN SHEE-UAN CHEN HSIN-FU CHEN YU-SHIH YANG |
Issue Date: | 1996 | Journal Volume: | 175 | Journal Issue: | 5 | Start page/Pages: | 1236-1241 | Source: | American Journal of Obstetrics and Gynecology | Abstract: | OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1β interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-α were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin- 1β interleukin-6, and tumor necrosis factor-α and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460169 | ISSN: | 0002-9378 | DOI: | 10.1016/S0002-9378(96)70034-0 | SDG/Keyword: | gamma interferon; gonadorelin agonist; interleukin 1beta; interleukin 2; interleukin 6; tumor necrosis factor alpha; adult; article; cell proliferation; clinical article; controlled study; endometriosis; female; human; human cell; immune deficiency; immunomodulation; interferon production; peritoneal fluid; priority journal; T lymphocyte; T lymphocyte activation |
Appears in Collections: | 醫學系 |
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