https://scholars.lib.ntu.edu.tw/handle/123456789/460412
標題: | Norplant® subdermal contraceptive system: Experience in Taiwan | 作者: | LI-HUI TSENG Lee T.-Y. YU-SHIH YANG TSANG-MING KO Chuang S.-M. |
公開日期: | 1996 | 卷: | 53 | 期: | 3 | 起(迄)頁: | 177-180 | 來源出版物: | Contraception | 摘要: | From November 1988 to December 1994, a total of 567 female volunteers were enrolled in Norplant? implant studies at the National Taiwan University Hospital. After a median follow-up of 29 months, only 3 of the 529 available cases became pregnant (a cumulative rate of 1.2 pregnancies per 100 users over 5 years). Chromosome analysis of 2 of the 3 abortuses revealed 46,XX/46,XX,inv(3) and 46,XX. Menstrual problems were the most common adverse effects and were also the main reason for discontinuation (65%, 108/166). The continuation rate was 90%, 78%, 70%, 61%, and 42% at the end of 1, 2, 3, 4, and 5 years after insertion, respectively. In the 21 patients who wished to become pregnant, fertility recurred soon after removal of the Norplant implants. The data suggested that the Norplant implants system is a highly effective, safe, and long-acting method of reversible contraception. It would be worthwhile to introduce this contraceptive system into Taiwan's family planning program. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460412 | ISSN: | 0010-7824 | DOI: | 10.1016/0010-7824(96)00007-8 | SDG/關鍵字: | levonorgestrel; contraceptive agent; levonorgestrel; acne; adult; amenorrhea; article; clinical trial; controlled clinical trial; controlled study; depression; drug efficacy; drug implantation; drug safety; female; fetus wastage; genotoxicity; headache; hormonal contraception; human; insomnia; major clinical study; menstrual irregularity; nausea; oral drug administration; weight gain; weight reduction; Asia; chemically induced disorder; China; chromosome aberration; contraception; Contraception Continuation; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Contraceptive Effectiveness; Contraceptive Implants; Contraceptive Methods; Contraceptive Usage; developing country; Diseases; drug implant; Eastern Asia; family planning; follow up; induced abortion; Levonorgestrel--side effects; menstruation disorder; methodology; newborn disease; pregnancy; Research Report; Reversibility; Studies; Taiwan; time; Asia; China; Chromosome Abnormalities; Contraception; Contraception Continuation; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Contraceptive Effectiveness; Contraceptive Implants; Contraceptive Methods; Contraceptive Usage; Developing Countries; Diseases; Eastern Asia; Family Planning; Follow-up Studies; Levonorgestrel--side effects; Neonatal Diseases And Abnormalities; Research Methodology; Research Report; Reversibility; Studies; Taiwan; Abortion, Induced; Chromosome Aberrations; Contraceptive Agents, Female; Drug Implants; Female; Humans; Levonorgestrel; Menstruation Disturbances; Pregnancy; Taiwan; Time Factors |
顯示於: | 醫學系 |
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