Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II Genes
Journal
Genomics
Journal Volume
29
Journal Issue
1
Pages
240-246
Date Issued
1995
Author(s)
Qiu Y.
Krishnan V.
Zeng Z.
Gilbert D.J.
Copeland N.G.
Gibson L.
Yang-Feng T.
Jenkins N.A.
Tsai S.Y.
Abstract
Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TF homologues have been cloned in many species, from Drosophila to human. The protein sequences of COUP-TFs are highly homologous across species, suggesting functional conservation. Two COUP-TF genes have been cloned from human, and their genomic organizations have been characterized. To determine whether the genomic organization is conserved between human and mouse, we isolated two mouse COUP-TF genes (I and II) and characterized their genomic structures. Both genes have relatively simple structures that are similar to those of their human counterparts. In addition, we mapped mouse COUP-TF I to the distal region of chromosome 13 and COUP-TF II to the central region of chromosome 7. Furthermore, we mapped human COUP-TF I to 5q14 of chromosome 5 and COUP-TF II to 15q26 of chromosome 15. The results demonstrate that COUP-TF genes are located in chromosomal regions that are syntenic between mouse and human.
SDGs
Type
journal article