A steroid response element can function in the absence of a distal promoter
Journal
Molecular Endocrinology
Journal Volume
2
Journal Issue
12
Pages
1286-1293
Date Issued
1988
Author(s)
Abstract
The glucocorticoid-progesterone responsive element (GRE/PRE) of the tyrosine aminotransferase (TAT) gene is a steroid-inducible enhancer. We show that the GRE/PRE can also work in the absence of a distal promoter element when located 5' to the ovalbumin TATA box. The GRE/PRE in this position retains progesterone or glucocorticoid receptor and hormone dependency for the induction of gene expression. Initiation of transcription occurs correctly, and induction occurs at the mRNA level. These data indicate that a steroid-inducible enhancer can function without a distal promoter element.
Type
journal article