Bioactivity investigation of lauraceae trees grown in Taiwan
Journal
Pharmaceutical Biology
Journal Volume
45
Journal Issue
8
Pages
638-644
Date Issued
2007
Author(s)
Abstract
This research collected 27 Lauraceae tree species in Taiwan, and the extracts prepared from leaves and branches were selected to evaluate and characterize their putative bioactivities and potential medicinal applications. Several bioactivity assays, including antifungal tests, antioxidant evaluation, anti-inflammation activity, and cytotoxicity were preformed in this study.The results showed no significant antifungal activity by Lauraceae extracts. Neolitsea parvigemma (Hay.) Kanehira et Sasaki expresses the best antioxidant activity (IC50 = 5.73 μg/mL) in the DPPH assay.The extracts of Litsea akoensis Hay. and Cryptocarya concinna Hance had significant anti-inflammation activity, and they can inhibit the nitric oxide (NO) production in the LPS-induced microphage assay at the dose of 25 μg/mL. According to the cytotoxicity assay, Lindera aggregate (Sims) Kosterm and Cryptocarya concinna Hance extracts showed in vitro cytotoxicity against human umbilical vein endothelial cell line (HUVEC) with IC50 values of 43.15 μg/mL and 49.36 μg/mL, respectively, and Phoebe formosana (Matsum. et Hay.) Hay. extract exhibited marked cytotoxicity (IC50 = 42.87 μg/mL) against a human leukemia cell line (HL-60). Results from this preliminary investigation suggest that these Lauraceae tree species may have a great potential for further development as cancer chemoprevention agents or food supplements for promoting human health. ?2007 Informa Healthcare USA, Inc.
SDGs
Other Subjects
Beilschmiedia erythrophloia extract; Cinnamomum camphora extract; Cinnamomum iners extract; Cinnamomum insularimontanum extract; Cinnamomum kanehirai extract; Cinnamomum osmophloeum extract; Cinnamomum philippinense extract; Cinnamomum subavenium extract; cinnamomum zeylanicum extract; Cryptocarya concinna extract; Lindera aggregate extract; Lindera communis extract; Lindera megaphylla extract; Litsea acuminata extract; Litsea akoensis extract; Litsea cubeba extract; Litsea kostermansii extract; Litsea rotundifolia extract; Machilus kusanoi extract; Machilus thunbergii extract; Machilus zuihoensis extract; Neolitsea konishii extract; Neolitsea parvigemma extract; Neolitsea sericea extract; Neolitsea variabillima extract; nitric oxide; Nothaphoebe konishii extract; Phoebe formosana extract; plant extract; unclassified drug; unindexed drug; angiosperm; animal cell; antifungal activity; antiinflammatory activity; antioxidant activity; article; Beilschmiedia erythrophloia; biological activity; cell assay; cell line; cell strain HL 60; Cinnamomum camphora; Cinnamomum iners; Cinnamomum insularimontanum; Cinnamomum kanehirai; Cinnamomum osmophloeum; Cinnamomum philippinense; Cinnamomum subavenium; Cinnamomum zeylanicum; controlled study; Cryptocarya concinna; cytotoxicity; drug activity; drug determination; drug potency; drug research; drug synthesis; endothelium cell; human; human cell; IC 50; leukemia cell; Lindera aggregate; Lindera communis; Lindera megaphylla; Litsea acuminata; Litsea akoensis; litsea cubeba; Litsea kostermansii; Litsea rotundifolia; Machilus kusanoi; Machilus thunbergii; Machilus zuihoensis; medicinal plant; mouse; Neolitsea konishii; Neolitsea parvigemma; Neolitsea sericea; Neolitsea variabillima; nonhuman; Nothaphoebe konishii; Phoebe formosana; plant growth; plant leaf; Taiwan; umbilical vein; Cryptocarya concinna; Lauraceae; Lindera; Litsea akoensis; Neolitsea parvigemma; Phoebe formosana
Type
journal article