Comparison of dexmedetomidine versus propofol on hemodynamics in surgical critically ill patients
Journal
Journal of Surgical Research
Journal Volume
228
Pages
194-200
Date Issued
2018
Author(s)
Chang, Ya-Fei
Chen, Lee-Wei
NTUH Center of Microcirculation Medical Research (NCMMR)
Abstract
Sedation with dexmedetomidine and propofol may cause hypotension or bradycardia. This study aimed to compare the effects of dexmedetomidine and propofol on hemodynamics and clinical outcomes in surgical intensive care unit (ICU) patients after major abdominal surgery. Enrolled patients were randomly allocated to the dexmedetomidine or propofol group. Cardiac index was measured using a continuous noninvasive cardiac output monitor on the basis of chest bioreactance. Heart rate, blood pressure, opioid requirement, urine output, delirium incidence, ICU length of stay, and total hospital length of stay were compared between the two groups. The incidences of bradycardia, hypotension, and severe low cardiac index were compared. We enrolled 60 patients. Heart rate and mean arterial pressure were significantly lower in the dexmedetomidine group than in the propofol group. Cardiac index did not differ significantly between the two groups (dexmedetomidine group 3.1 L/min/m2, [95% confidence interval {95% CI} 2.8-3.3] versus propofol group 3.2 L/min/m2 [95% CI 2.9-3.5], P = 0.578). The incidences of bradycardia, hypotension, and severe low cardiac index did not differ significantly between the two groups. Cardiac index did not differ significantly between the dexmedetomidine and propofol groups in surgical ICU patients after major abdominal surgery.
SDGs
Other Subjects
dexmedetomidine; opiate; propofol; dexmedetomidine; narcotic analgesic agent; propofol; abdominal surgery; aged; Article; blood pressure; bradycardia; cardiac index; controlled study; critically ill patient; delirium; female; heart output; heart rate; hemodynamics; human; hypotension; length of stay; major clinical study; male; mean arterial pressure; priority journal; randomized controlled trial; surgical intensive care unit; urine volume; analgesia; bradycardia; chemically induced; comparative study; critical illness; delirium; drug effect; hemodynamics; hypotension; incidence; intensive care; intensive care unit; middle aged; pain measurement; postoperative care; postoperative pain; procedures; statistics and numerical data; surgery; treatment outcome; very elderly; Aged; Aged, 80 and over; Analgesics, Opioid; Bradycardia; Critical Care; Critical Illness; Delirium; Dexmedetomidine; Female; Hemodynamics; Humans; Hypotension; Incidence; Intensive Care Units; Length of Stay; Male; Middle Aged; Pain Management; Pain Measurement; Pain, Postoperative; Postoperative Care; Propofol; Surgical Procedures, Operative; Treatment Outcome
Publisher
Academic Press Inc.
Type
journal article