Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma
Journal
Pancreas
Journal Volume
38
Journal Issue
4
Pages
422-426
Date Issued
2009
Author(s)
Abstract
OBJECTIVES: A prior study suggested serum heat shock protein 27 (HSP27) as a potential marker for pancreatic carcinoma, but its accuracy in differentiating cancer from chronic pancreatitis was not evaluated. We aimed to analyze HSP27 levels in pancreatic carcinoma, chronic pancreatitis, and healthy subjects and assess its diagnostic efficacy. METHODS: Pretreatment serums from 58 pancreatic carcinoma, 44 chronic pancreatitis, and 102 control subjects were collected. Serum HSP27 and carbohydrate antigen 19-9 (CA19-9) levels were analyzed using an enzyme-linked immunosorbent assay and radioimmunoassay, respectively. RESULTS: Heat shock protein 27 levels were significantly higher in cancer and pancreatitis compared with control (P < 0.001 for both), but no significant difference was noted between cancer and pancreatitis (P = 0.978). By logistic regression, HSP27 was a significant predictor of differentiation between cancer and control (P < 0.0001) but not between cancer and pancreatitis (P = 0.885). At a cutoff of 1650 ng/L, the sensitivity and specificity for differentiating cancer from healthy control were 62.1% and 95.1%, respectively. Receiver operating characteristic analyses showed a greater area under curve for CA19-9 compared with HSP27 in differentiating between cancer and control (0.92 and 0.84, respectively, P = 0.014). CONCLUSIONS: Serum HSP27 is increased in both chronic pancreatitis and pancreatic carcinoma. It should not be recommended as a diagnostic marker for pancreatic carcinoma. ? 2009 Lippincott Williams & Wilkins, Inc.
SDGs
Other Subjects
biological marker; CA 19-9 antigen; heat shock protein 27; CA 19-9 antigen; heat shock protein 27; tumor marker; adult; aged; area under the curve; article; blood level; chronic pancreatitis; controlled study; diagnostic value; differential diagnosis; enzyme linked immunosorbent assay; female; human; logistic regression analysis; major clinical study; male; pancreas carcinoma; priority journal; protein expression; radioimmunoassay; receiver operating characteristic; sensitivity and specificity; statistical analysis; blood; middle aged; pancreas tumor; prediction and forecasting; Adult; Aged; CA-19-9 Antigen; Enzyme-Linked Immunosorbent Assay; Female; HSP27 Heat-Shock Proteins; Humans; Male; Middle Aged; Pancreatic Neoplasms; Pancreatitis, Chronic; Predictive Value of Tests; Tumor Markers, Biological
Type
journal article