https://scholars.lib.ntu.edu.tw/handle/123456789/462112
Title: | Percutaneous ethanol injection versus surgical resection for the treatment of small hepatocellular carcinoma: A prospective study | Authors: | GUAN-TARN HUANG PO-HUANG LEE Tsang Y.-M. Lai M.-Y. PEI-MING YANG REY-HENG HU PEI-JER CHEN JIA-HORNG KAO JIN-CHUAN SHEU Lee, Cha-Ze DING-SHINN CHEN |
Issue Date: | 2005 | Publisher: | Lippincott Williams and Wilkins | Journal Volume: | 242 | Journal Issue: | 1 | Start page/Pages: | 36-42 | Source: | Annals of Surgery | Abstract: | Objective: To compare disease recurrence and survival among patients with small hepatocellular carcinoma after surgical resection or percutaneous ethanol injection therapy, 2 treatments that have not been evaluated with a prospective study. Methods: A total of 76 patients were randomly assigned to 2 groups based on treatment; all had one or 2 tumors with diameter ?3 cm, with hepatitis without cirrhosis or Child class A or B cirrhosis without evident ascites or bleeding tendency. Results: Follow-up ranged from 12 to 59 months. Among percutaneous injection patients, 18 had recurrence 1 to 37 months after treatment (true recurrence, 11; original safety margin inadequate, 3; limitation of imaging technology to detect tiny tumors, 4). Three injection therapy patients died of cancer 25, 37, and 57 months after treatment. For the surgical resection group, 15 had recurrence 2 to 54 months after treatment (true recurrence, 12; limitation of imaging, 2; neck metastasis, 1). Five resection patients died of cancer at 11, 20, 23, 26, and 52 months, respectively. By Cox regression model and Kaplan-Meier survival analysis, there is no statistical significance for recurrence and survival between treatment groups. However, tumor size larger than 2 cm and alpha-fetoprotein over 200 ng/mL correlated with higher recurrence rate, and Child class B liver cirrhosis correlated with shorter survival. Conclusions: Percutaneous ethanol injection therapy appears to be as safe and effective as resection, and both treatments can be considered first-line options for small hepatocellular carcinoma. Copyright ? 2005 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984533393&doi=10.1097%2f01.sla.0000167925.90380.fe&partnerID=40&md5=30f80f525e48cae85c667b11743259ec https://scholars.lib.ntu.edu.tw/handle/123456789/462112 |
ISSN: | 0003-4932 | DOI: | 10.1097/01.sla.0000167925.90380.fe | SDG/Keyword: | alcohol; alpha fetoprotein; adult; aged; article; cancer mortality; cancer surgery; clinical trial; comparative study; controlled clinical trial; controlled study; diagnostic imaging; female; follow up; hepatitis; human; injection; Kaplan Meier method; liver cell carcinoma; liver cirrhosis; liver resection; lobectomy; major clinical study; male; neck metastasis; percutaneous ethanol injection therapy; priority journal; prognosis; prospective study; randomized controlled trial; recurrent disease; regression analysis; safety; survival rate; tumor recurrence; tumor volume |
Appears in Collections: | 醫學系 |
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