https://scholars.lib.ntu.edu.tw/handle/123456789/463639
標題: | The impact of nocturnal disturbances on daily quality of life in patients with Parkinson's disease | 作者: | Yu R.-L Tan C.-H RUEY-MEEI WU |
關鍵字: | Non-motor symptoms; Parkinson’s disease; Quality of life; Sleep | 公開日期: | 2015 | 卷: | 11 | 起(迄)頁: | 2005-2012 | 來源出版物: | Neuropsychiatric Disease and Treatment | 摘要: | Objectives: The aims of this study were to explore nocturnal disturbances in patients with Parkinson’s disease (PD) and to assess their impact on quality of life (QoL). Methods: A total of 211 patients with PD were recruited for this study, and each participant was evaluated using the mini-mental state examination, PD sleep scale – second version (PDSS-2), pittsburgh sleep quality index (PSQI), PD QoL questionnaire (PDQ), Epworth sleepiness scale, Hoehn and Yahr (H&Y) staging, and unified Parkinson’s disease rating scale (UPDRS). Multiple regression analyses were performed to determine the contribution of the predictive variables on QoL. Results: There were 56.4% males (mean age: 64.08 years; disease duration: 6.02 years; H&Y stage: 2.25; and UPDRS: 33.01) in this study. Our patients’ actual sleep time was 5.96±1.16 hours and the average sleep efficiency was 82.93%±12.79%. Up to 64.4% of patients were classified as “poor” sleepers and 23.8% suffered from daytime sleepiness. The final stepwise regression model revealed that UPDRS parts I and II, the sleep disturbance and daytime dysfunction components of the PSQI, the PD symptoms at night subscale of the PDSS-2, and the levodopa equivalent dose were significant predictors of the PDQ score (R2=53, F7,165=28.746; P<0.001). Conclusion: Most of the PD patients have sleep problems, and nearly one-quarter of them have abnormal daytime somnolence. The nocturnal disturbances were found to result in worse QoL in PD patients. Ethnicity-specific effects of susceptibility to sleep disturbances were discussed, and these results also highlighted the direction for further studies to explore when examining effective management programs toward these disturbances. ? 2015 Yu et al. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463639 | ISSN: | 1176-6328 | DOI: | 10.2147/NDT.S85483 | SDG/關鍵字: | levodopa; adult; Article; daytime somnolence; disease association; disease duration; Epworth sleepiness scale; female; Hoehn and Yahr scale; human; major clinical study; male; Mini Mental State Examination; Parkinson disease; Parkinson Disease quality of life questionnaire; Parkinson Disease sleep scale; Pittsburgh Sleep Quality Index; quality of life; questionnaire; rating scale; sleep disorder; sleep time; Unified Parkinson Disease Rating Scale |
顯示於: | 醫學系 |
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